暴露于高渗溶液的离体大鼠心房对去甲肾上腺素的反应性降低。
Reduced responsiveness to noradrenaline in isolated rat atria exposed to hyperosmotic solutions.
作者信息
Bassani R A, Bassani J W
机构信息
Departamento de Engenharia Biomédica, Faculdade de Engenharia Elétrica, Universidade Estadual de Campinas, SP, Brazil.
出版信息
Gen Pharmacol. 1991;22(1):151-7. doi: 10.1016/0306-3623(91)90326-2.
PMID:2050282
Abstract
- The effects of hyperosmotic NaCl and sucrose solutions on the responsiveness to noradrenaline (NA) were studied in isolated rat right and left atria. 2. Sucrose caused subsensitivity to NA and isoprenaline in right atria, which was abolished by atropine. 3. NaCl caused subsensitivity only to NA in both atria, which was reversed by imipramine. 4. Both solutions decreased the maximum tension of left atria after maximal NA and Ca2+ concentrations. 5. The results suggest that hyperosmolality reduces the atrial responsiveness to NA by directly depressing contractility and increasing acetylcholine release. However, if the solute is NaCl, the main mechanism seems to be an increase of the catecholamine neuronal uptake.
摘要
- 在离体大鼠右心房和左心房中研究了高渗氯化钠和蔗糖溶液对去甲肾上腺素（NA）反应性的影响。2. 蔗糖使右心房对NA和异丙肾上腺素产生反应性降低，阿托品可消除这种作用。3. 氯化钠仅使两个心房对NA产生反应性降低，丙咪嗪可使其逆转。4. 两种溶液均降低了在最大NA和Ca2+浓度后左心房的最大张力。5. 结果表明，高渗状态通过直接抑制收缩力和增加乙酰胆碱释放来降低心房对NA的反应性。然而，如果溶质是氯化钠，主要机制似乎是儿茶酚胺神经元摄取增加。
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