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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Laboratory of Pharmacology, School of Pharmaceutical Sciences, UNESP, Araraquara, Brazil.

Gen Pharmacol. 1991;22(1):93-7. doi: 10.1016/0306-3623(91)90315-w.

Norepinephrine (NE) and clonidine produce a phasic, dose-dependent contraction of the isolated guinea-pig terminal ileum. 2. The effect of NE was blocked by prazosin which produced a parallel rightward shift of the concentration-effect curve to NE, with a significant depression of maximum effects. 3. Yohimbine and indomethacin noncompetitively blocked, whereas practolol potentiated, the contractile effect of NE. 4. The contractile effect of clonidine was not antagonized by indomethacin or atropine. 5. These results suggest that the isolated guinea-pig terminal ileum has excitatory receptors sensitive to clonidine stimulation and excitatory alpha receptors sensitive to blockade by prazosin, and that the activation of the latter may be related to the activation of endogenous prostaglandin synthesis.

去甲肾上腺素（NE）和可乐定可使离体豚鼠回肠末端产生阶段性、剂量依赖性收缩。2. 哌唑嗪可阻断NE的作用，使NE的浓度-效应曲线平行右移，最大效应显著降低。3. 育亨宾和吲哚美辛非竞争性阻断NE的收缩作用，而醋氨心安则增强其收缩作用。4. 吲哚美辛或阿托品不能拮抗可乐定的收缩作用。5. 这些结果表明，离体豚鼠回肠末端具有对可乐定刺激敏感的兴奋性受体和对哌唑嗪阻断敏感的兴奋性α受体，后者的激活可能与内源性前列腺素合成的激活有关。

Laboratory of Pharmacology, School of Pharmaceutical Sciences, UNESP, Araraquara, Brazil.

Gen Pharmacol. 1991;22(1):93-7. doi: 10.1016/0306-3623(91)90315-w.

Norepinephrine (NE) and clonidine produce a phasic, dose-dependent contraction of the isolated guinea-pig terminal ileum. 2. The effect of NE was blocked by prazosin which produced a parallel rightward shift of the concentration-effect curve to NE, with a significant depression of maximum effects. 3. Yohimbine and indomethacin noncompetitively blocked, whereas practolol potentiated, the contractile effect of NE. 4. The contractile effect of clonidine was not antagonized by indomethacin or atropine. 5. These results suggest that the isolated guinea-pig terminal ileum has excitatory receptors sensitive to clonidine stimulation and excitatory alpha receptors sensitive to blockade by prazosin, and that the activation of the latter may be related to the activation of endogenous prostaglandin synthesis.

去甲肾上腺素（NE）和可乐定可使离体豚鼠回肠末端产生阶段性、剂量依赖性收缩。2. 哌唑嗪可阻断NE的作用，使NE的浓度-效应曲线平行右移，最大效应显著降低。3. 育亨宾和吲哚美辛非竞争性阻断NE的收缩作用，而醋氨心安则增强其收缩作用。4. 吲哚美辛或阿托品不能拮抗可乐定的收缩作用。5. 这些结果表明，离体豚鼠回肠末端具有对可乐定刺激敏感的兴奋性受体和对哌唑嗪阻断敏感的兴奋性α受体，后者的激活可能与内源性前列腺素合成的激活有关。