The objective of this technical note is to describe the autologous matrix induced chondrogenesis (AMIC) procedure and to evaluate its possible role for resurfacing of retropatellar cartilage defects. AMIC is a one-step procedure combining microfracturing with application of a collagen I/III membrane to protect the initial blood clot and to serve as a scaffold for the developing chondrocytes. A retrospective analysis of our experience in three patients followed for 18 months is presented.