Department of Chemistry, University of Massachusetts at Amherst, Amherst, Massachusetts 01003, USA.
J Am Chem Soc. 2010 Jun 23;132(24):8246-7. doi: 10.1021/ja102316a.
The stability of encapsulation in self-assembly systems is limited during blood circulation because of a requisite concentration for assembly formation. For deliberate molecular design for stable encapsulation, targeting, and triggered release, we have developed a facile synthetic method for highly stable, polymeric nanogels using a simple intra/interchain cross-linking reaction. We show a simple, emulsion-free method for the preparation of biocompatible nanogels that provides the ability to encapsulate hydrophobic guest molecules and surface functionalization which has potential for targeted delivery. We show that the noncovalently encapsulated guest molecules can be released in response to a biologically relevant stimulus.
自组装体系中的包封稳定性在血液循环过程中受到限制，因为组装形成需要一定的浓度。为了进行稳定包封、靶向和触发释放的精心分子设计，我们开发了一种使用简单的链内/链间交联反应制备高稳定聚合物纳米凝胶的简便合成方法。我们展示了一种简单的、无乳液的方法来制备生物相容性纳米凝胶，该方法提供了封装疏水分子和表面功能化的能力，具有靶向递送的潜力。我们表明，非共价包封的客体分子可以响应生物相关刺激进行释放。
