Ministry of Health, Etlik Zubeyde Hanim Women's Health Research Hospital, Obstetrics and Gynecology, Ankara, Turkey.
Gynecol Endocrinol. 2010 Nov;26(11):833-7. doi: 10.3109/09513590.2010.487591.
To investigate the effects of endometrial thickness measurements and serum hormone levels on the outcomes of GnRH antagonist down-regulated ICSI cycles.
Forty consecutive infertile women undergoing controlled ovarian hyperstimulation with recombinant FSH and GnRH antagonists for ICSI were enrolled in this study. All patient's age, day 3 FSH, antral follicle count (AFC), serum E2 levels on day 3, E2 on stimulation day 5, E2 on day of hCG administration, endometrial thickness on the baseline (ETMBaseline), on day 5 of stimulation (ETMDay 5), on day of hCG administration (ETMhCG) and cycle outcomes were recorded. The outcomes of pregnant and nonpregnant women were compared.
Women's age was 33.6 +/- 4.9. Overall pregnancy rate was 45% (n = 18), clinical pregnancy rate was 27.5% (n = 11) and ongoing pregnancy rate was 20% (n = 8). In pregnant women, baseline AFC was significantly higher compared with nonpregnant women (p = 0.01). There was no significant correlation between ETMhCG and E2 level on the day of hCG, number of retrieved oocytes or patients' age.
For achieving pregnancy, endometrial thickness on the day of hCG is not a determining parameter, and the only significant determinent is AFC in GnRH antagonist down-regulated ICSI cycles.
探讨子宫内膜厚度测量和血清激素水平对 GnRH 拮抗剂下调的 ICSI 周期结局的影响。
本研究纳入了 40 名连续接受重组 FSH 和 GnRH 拮抗剂控制性卵巢超刺激以进行 ICSI 的不孕妇女。所有患者的年龄、第 3 天 FSH、窦卵泡计数（AFC）、第 3 天血清 E2 水平、第 5 天刺激时的 E2、HCG 给药日的 E2、基础内膜厚度（ETMBaseline）、刺激第 5 天的内膜厚度（ETMDay 5）、HCG 给药日的内膜厚度（ETMhCG）和周期结局均被记录。比较了妊娠和非妊娠妇女的结局。
妇女的年龄为 33.6±4.9 岁。总体妊娠率为 45%（n=18），临床妊娠率为 27.5%（n=11），持续妊娠率为 20%（n=8）。在妊娠妇女中，基础 AFC 明显高于非妊娠妇女（p=0.01）。ETMhCG 与 HCG 给药日的 E2 水平、获卵数或患者年龄之间均无显著相关性。
对于实现妊娠而言，HCG 给药日的子宫内膜厚度不是一个决定因素，在 GnRH 拮抗剂下调的 ICSI 周期中，唯一显著的决定因素是 AFC。
