Hu Rui, Tian Chao, Meng Wen-jian, Zhang Jian-hui, Li Lui, Zhang Pu-rong, Long Qi-ming, Tao Ping
Department of Mastologic Surgery, Sichuan Cancer Hospital, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Mar;41(2):231-4.
To investigate the expression of Wnt-1 induced secreted protein-1 (WISP-1) between breast cancer and paired normal breast tissues and to explore the significance of WISP-1 in breast cancer tumorigenesis.
The mRNA and protein expressions of WISP-1 in human breast cancer were measured by Quantitative Real-Time RT-PCR and immunohistochemical staining and further analyzed the relationship between WISP-1 expression and clinic pathologic characters.
WISP-1 expression in breast cancer was higher than that in normal breast tissue (P = 0.001). The mRNA expression level of WISP-1 was correlated with tumor size, staging, lymph node status, differentiated degree and HER-2 status (P < 0.05). WISP-1 protein expression level was correlated with lymph node status, differentiated degree and HER-2 status (P < 0.05).
WISP-1 expression in human breast cancer increases significantly and may play a key role in the invasion and metastasis of human breast cancer.
