Area de Farmacologia, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo (IMBECU-FCM, CONICET), Argentina.
Pharmacol Rep. 2010 Mar-Apr;62(2):265-72. doi: 10.1016/s1734-1140(10)70265-6.
In the present paper we show for the first time that pregnenolone sulfate (Preg-S) impairs rats' memory for novel object recognition when injected in lateral septum (1.2 microM). The effect of Preg-S is clearly related to the moment the reagent is administered: if administered shortly after the training phase, or prior to the test phase of the experiment, there is no amnesic effect. It is only amnesic when administered 30 min before training. Accordingly, Preg-S does not appear to affect the storage of new memories or their retrieval but rather the acquisition itself. Based on the described afferences and efferences of lateral septum, we suggest a possible stimulatory effect of Preg-S regarding glutamate receptors and/or an inhibitory effect of GABA receptors located in local interneurons or recurrent axon collaterals, both of which have been reported to exist in the aforementioned nucleus.
在本文中，我们首次表明，当将孕烯醇酮硫酸盐（Preg-S）注入侧脑室（1.2μM）时，它会损害大鼠对新物体识别的记忆。Preg-S 的作用显然与给药时间有关：如果在训练阶段后不久给药，或在实验的测试阶段之前给药，则没有健忘作用。只有在训练前 30 分钟给药时才会出现健忘症。因此，Preg-S 似乎不会影响新记忆的存储或检索，而是影响获取本身。基于侧脑室的描述性传入和传出，我们提出 Preg-S 可能对位于局部中间神经元或反复轴突侧支上的谷氨酸受体具有刺激作用，并且对 GABA 受体具有抑制作用，据报道这两种受体均存在于上述核中。
