比马前列素对猴房水动力学的影响。
Bimatoprost effects on aqueous humor dynamics in monkeys.
作者信息
Woodward David F, Krauss Achim H-P, Nilsson Siv F E
机构信息
Department of Biological Sciences, Allergan, Inc., Irvine, CA 92612, USA.
出版信息
J Ophthalmol. 2010;2010:926192. doi: 10.1155/2010/926192. Epub 2010 May 23.
The effects of bimatoprost on aqueous humor dynamics were quantified in monkey eyes. Uveoscleral outflow was measured by the anterior chamber perfusion method, using FITC-dextran. Total outflow facility was determined by the two-level constant pressure method. Aqueous flow was measured with a scanning ocular fluorophotometer. Uveoscleral outflow was 0.96 +/- 0.19 muL min(-1) in vehicle-treated eyes and 1.37 +/- 0.27 muL min(-1) (n = 6; P < .05) in eyes that received bimatoprost 0.01% b.i.d. x 5 days. Bimatoprost had no effect on total outflow facility, which was 0.42 +/- 0.05 muL min(-1) at baseline and 0.42 +/- 0.04 muL min(-1) after bimatoprost treatment. Bimatoprost had no significant effect on aqueous humor flow. This study demonstrates that bimatoprost increases uveoscleral outflow but not total outflow facility or aqueous humor flow, indicating that it lowers intraocular pressure in ocular normotensive monkeys by a mechanism that exclusively involves uveoscleral outflow.
在猴眼中对比马前列素对房水动力学的影响进行了量化。采用前房灌注法，使用异硫氰酸荧光素 - 葡聚糖测量葡萄膜巩膜流出量。通过两级恒压法测定总流出率。用扫描式眼荧光光度计测量房水流量。在接受载体治疗的眼中，葡萄膜巩膜流出量为0.96±0.19μL·min⁻¹，而在接受0.01%比马前列素每日两次、共5天治疗的眼中，葡萄膜巩膜流出量为1.37±0.27μL·min⁻¹（n = 6；P <.05）。比马前列素对总流出率无影响，基线时总流出率为0.42±0.05μL·min⁻¹，比马前列素治疗后为0.42±0.04μL·min⁻¹。比马前列素对房水流量无显著影响。本研究表明，比马前列素增加葡萄膜巩膜流出量，但不增加总流出率或房水流量，这表明它通过一种仅涉及葡萄膜巩膜流出的机制降低正常眼压猴的眼压。
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