肥胖症患者的人脂肪组织中炎症介质的释放增加，主要是非脂肪细胞：综述。
Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review.
机构信息
Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
出版信息
Mediators Inflamm. 2010;2010:513948. doi: 10.1155/2010/513948. Epub 2010 May 23.
Abstract
This paper considers the role of putative adipokines that might be involved in the enhanced inflammatory response of human adipose tissue seen in obesity. Inflammatory adipokines [IL-6, IL-10, ACE, TGFbeta1, TNFalpha, IL-1beta, PAI-1, and IL-8] plus one anti-inflammatory [IL-10] adipokine were identified whose circulating levels as well as in vitro release by fat are enhanced in obesity and are primarily released by the nonfat cells of human adipose tissue. In contrast, the circulating levels of leptin and FABP-4 are also enhanced in obesity and they are primarily released by fat cells of human adipose tissue. The relative expression of adipokines and other proteins in human omental as compared to subcutaneous adipose tissue as well as their expression in the nonfat as compared to the fat cells of human omental adipose tissue is also reviewed. The conclusion is that the release of many inflammatory adipokines by adipose tissue is enhanced in obese humans.
摘要
本文探讨了在肥胖人群中，可能参与增强人脂肪组织炎症反应的假定脂肪因子的作用。鉴定出了多种炎症脂肪因子[IL-6、IL-10、ACE、TGFbeta1、TNFalpha、IL-1beta、PAI-1 和 IL-8]和一种抗炎脂肪因子[IL-10]，它们在肥胖人群中的循环水平以及脂肪体外释放均增强，主要由人脂肪组织的非脂肪细胞释放。相比之下，瘦素和 FABP-4 的循环水平在肥胖人群中也升高，它们主要由人脂肪组织的脂肪细胞释放。还综述了人网膜脂肪组织中与皮下脂肪组织相比的脂肪因子和其他蛋白的相对表达，以及与脂肪细胞相比的非脂肪细胞中的表达。结论是，在肥胖人群中，脂肪组织释放许多炎症脂肪因子增加。
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