Wang Fan, Ye Ping, Xiao Wen-kai, Luo Lei-ming, Wu Hong-mei
Department of Geriatric Cardiology, The Chinese PLA General Hospital, Beijing 100853, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2010 Mar;31(3):256-9.
Data from several large prospective studies revealed that a low glomerular filtration rate was independently associated with cardiovascular disease (CVD) events and all-cause mortality in high-risk populations. Much on the association was explained by traditional CVD risk factors. However, findings from population-based studies were scarce and inconsistent. We explored the correlation between risks factors of cardiovascular and chronic kidney disease (CKD) in a general population from certain area of Beijing.
A population-based cross-sectional survey was conducted during Sep. 2007 to Oct. 2008 in Beijing. Out of 5100 individuals who were selected, 4515 met the inclusion criteria and responded to the investigation. By face to face interview, a questionnaire was used to find out the risk factors of cardiovascular disease. Body height, body weight and blood pressures were measured. Serum creatinine and total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) were detected. Glomerular filtration rate through using the Modification of Diet in Renal Disease equation was estimated. Participants were grouped into three: >/= 90, 60 - 89, < 60 [mlxmin(-1)x(1.73 m(2))(-1)] by eGFR. Univariate and multivariate logistic regression models were used to identify the associated risk factors.
Exposure rate of cardiovascular disease risk factors increased along with the decrease of level of eGFR. Data from univariate logistic regression analyses suggested that age, smoking, history of hypertension and diabetes, BMI, SBP, LDL-C and TG were risk factors of CKD while results from multiple logistic regression indicated that age, smoking, hypertension, high level of TG appeared to be independent risk factors of CKD.
Exposure rate of cardiovascular disease risk factors increased along with the decrease of level of eGFR while age, hypertension, high level of TG and smoking were independent risk factors of CKD.
多项大型前瞻性研究的数据显示，低肾小球滤过率与高危人群的心血管疾病（CVD）事件及全因死亡率独立相关。传统的CVD危险因素可解释这种关联的大部分情况。然而，基于人群的研究结果却很少且不一致。我们探讨了北京某地区普通人群中心血管疾病和慢性肾脏病（CKD）危险因素之间的相关性。
2007年9月至2008年10月在北京进行了一项基于人群的横断面调查。在入选的5100名个体中，4515名符合纳入标准并接受了调查。通过面对面访谈，使用问卷来找出心血管疾病的危险因素。测量身高、体重和血压。检测血清肌酐以及总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）。通过使用肾脏病饮食改良公式估算肾小球滤过率。根据估算的肾小球滤过率（eGFR）将参与者分为三组：≥90、60 - 89、<60 [ml·min⁻¹·(1.73 m²)⁻¹]。使用单因素和多因素逻辑回归模型来识别相关的危险因素。
心血管疾病危险因素的暴露率随着eGFR水平的降低而增加。单因素逻辑回归分析数据表明，年龄、吸烟、高血压和糖尿病史、体重指数（BMI）、收缩压（SBP）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）是CKD的危险因素，而多因素逻辑回归结果表明，年龄、吸烟、高血压、高甘油三酯水平似乎是CKD的独立危险因素。
心血管疾病危险因素的暴露率随着eGFR水平的降低而增加，而年龄、高血压、高甘油三酯水平和吸烟是CKD的独立危险因素。
