Division for Marine and Environmental Research, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia.
Environ Pollut. 2010 Aug;158(8):2686-93. doi: 10.1016/j.envpol.2010.04.020. Epub 2010 May 26.
A comprehensive study of various psychoactive substances and their metabolites was performed in the wastewater treatment plant of the city of Zagreb (780 000 inhabitants) using liquid chromatography/tandem mass spectrometry (LC-MS-MS). The estimation of drug abuse for five different illicit drugs, including heroin, cocaine, marijuana, amphetamine and ecstasy, was made on the basis of their representative excretion rates, which were determined over a period of 8 months. Marijuana (1000 kg/year), heroin (75 kg/year) and cocaine (47 kg/year) were found to be the most frequently consumed illicit drugs, while the consumption of amphetamine-type drugs was much lower (1-3 kg/year). A comparison with other reports indicated that drug abuse profiles in transition countries might be different from those reported for Western Europe, in particular with respect to the comparatively increased consumption of heroin. Enhanced consumption of stimulating drugs (cocaine and ectasy) was systematically detected during weekends.
采用液相色谱-串联质谱法（LC-MS-MS）对萨格勒布市（拥有 78 万居民）的污水处理厂中的各种精神活性物质及其代谢物进行了全面研究。基于其代表性排泄率，对包括海洛因、可卡因、大麻、苯丙胺和摇头丸在内的 5 种不同非法药物的药物滥用情况进行了估算，这些排泄率是在 8 个月的时间内确定的。结果发现，大麻（1000 公斤/年）、海洛因（75 公斤/年）和可卡因（47 公斤/年）是最常消费的非法药物，而苯丙胺类药物的消费则低得多（1-3 公斤/年）。与其他报告的比较表明，转型国家的药物滥用情况可能与西欧报告的情况不同，特别是海洛因的消费相对增加。在周末期间，还系统地检测到了刺激类药物（可卡因和摇头丸）消费的增强。
