Rovati L C
Department of Clinical Pharmacology, Rotta Research Laboratorium, Milan, Italy.
Int J Pancreatol. 1991 Apr;8(3):215-26. doi: 10.1007/BF02924540.
Cholecystokinin (CCK) is one of the most important regulators of pancreatic and digestive physiology. Its importance led to research and discovery of a number of CCK receptor antagonists. Some of them are experimentally and clinically used today in order to assess the relative contribution of CCK to different aspects of pancreatic physiology. Furthermore, clinical trials are running with the aim of determining their possible therapeutic indications in pancreatic diseases, such as acute and chronic pancreatitis or pancreatic carcinoma. The rationale and evidence for their use are discussed.
胆囊收缩素（CCK）是胰腺和消化生理学最重要的调节因子之一。其重要性促使人们开展了多项关于CCK受体拮抗剂的研究与发现。如今，其中一些拮抗剂已在实验和临床中得到应用，以评估CCK在胰腺生理学不同方面的相对作用。此外，正在进行临床试验，旨在确定它们在胰腺疾病（如急性和慢性胰腺炎或胰腺癌）中的可能治疗适应症。文中讨论了使用这些拮抗剂的基本原理和证据。
