Department of Surgery, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Best Pract Res Clin Gastroenterol. 2010 Jun;24(3):311-22. doi: 10.1016/j.bpg.2010.03.001.
There is probably no other gastrointestinal disorder which is as much characterized by concomitant local, intra-organ and central neuropathic and neuroplastic alterations as chronic pancreatitis (CP). While some key features of this neuropathy have recently been elucidated, there is still no satisfying pathophysiological explanation for the generation of neuropathic pain in CP. It is becoming increasingly clear that an effective pain treatment in CP can probably not be achieved without consideration of the exact fate of intrapancreatic nerves and central neuroplastic alterations. This review is intended to illustrate the temporal and spatial alterations of intrapancreatic nerves in the course of CP. At the same time, it depicts the reciprocal relationship between these plastic changes and thus underlines the notion of a 'common fate' for all these alterations. Moreover, it points out numerous aspects of this fate that are yet to be unveiled and should therefore be subject to future investigation.
可能没有其他胃肠道疾病像慢性胰腺炎（CP）那样具有如此明显的局部、器官内和中枢神经病变和神经重塑改变。虽然这种神经病变的一些关键特征最近已经阐明，但对于 CP 中神经性疼痛的产生仍然没有令人满意的病理生理学解释。越来越清楚的是，如果不考虑胰腺内神经和中枢神经重塑改变的确切命运，CP 中的有效疼痛治疗可能无法实现。这篇综述旨在说明 CP 过程中胰腺内神经的时空改变。同时，它描述了这些可塑性变化之间的相互关系，从而强调了所有这些变化的“共同命运”概念。此外，它指出了这一命运中仍有许多尚未揭示的方面，因此应该是未来研究的主题。
