在 BMP 介导的 NMJ 逆行信号转导过程中发生三人混居现象。
Ménage à Trio during BMP-Mediated Retrograde Signaling at the NMJ.
机构信息
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
出版信息
Neuron. 2010 May 27;66(4):473-5. doi: 10.1016/j.neuron.2010.05.016.
Abstract
In flies, retrograde BMP signaling is an important mechanism by which postsynaptic cells regulate the structure and function of presynaptic terminals, ostensibly through changes in gene expression. Transcriptional targets, however, have remained mysterious. In this issue of Neuron, Haghighi and colleagues begin to unravel this puzzle by identifying the cytoskeletal regulator Trio.
摘要
在果蝇中，逆行 BMP 信号是一种重要的机制，通过这种机制，突触后细胞调节突触前末梢的结构和功能，表面上是通过基因表达的变化。然而，转录靶标一直是个谜。在本期《神经元》杂志上，Haghighi 及其同事通过鉴定细胞骨架调节剂 Trio 开始揭开这个谜团。
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