Department of Electronic Chemistry, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, Mail Box G1-5, 4259 Nagastuta, Midori-ku, Yokohama 226-8502, Japan.
Anal Chim Acta. 2010 Jun 11;669(1-2):75-80. doi: 10.1016/j.aca.2010.04.048. Epub 2010 May 14.
The present article demonstrates the electrochemical oxidation of uric acid (UA) at sulfur-adlayer-coated gold (S-Au) electrode in alkaline media. At S-Au electrode, UA oxidized at a significantly lower overpotential with a higher current density as compared to the bare Au electrode. The oxidation of UA at the S-Au electrode is highly selective in the presence of the other commonly existing bio-molecules in urine. The proposed electrochemical sensor not only exhibited good reproducibility, but also showed a fast amperometric response to UA in the concentration range of 0.0025-5 mM with a low detection limit of 0.4 microM.
本文展示了在碱性介质中，通过硫层修饰金（S-Au）电极实现尿酸（UA）电化学氧化的过程。与裸 Au 电极相比，S-Au 电极上 UA 的氧化具有更低的过电势和更高的电流密度。在尿液中常见的其他生物分子存在的情况下，UA 在 S-Au 电极上的氧化具有高度选择性。所提出的电化学传感器不仅表现出良好的重现性，而且对 0.0025-5 mM 浓度范围内的 UA 具有快速的安培响应，检测限低至 0.4 microM。
