Department of Radiation Oncology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.
Breast. 2010 Jun;19(3):192-7. doi: 10.1016/j.breast.2010.03.003.
A large amount of clinical evidence has recently accumulated supporting the efficacy and safety of hypofractionated radiotherapy for post-operative breast cancer. These schedules, typically delivering a lower total dose in fewer, but larger than 2 Gy fractions, are more convenient for the patients by limiting the number of treatment attendances. Moreover, the reduced resource use in terms of personnel and machine time is advantageous for radiotherapy departments and translates into lower treatment costs. In order to formally validate this therapeutic approach from a societal perspective, however, cost-effectiveness evaluations weighing long-term outcome against the societal costs incurred until many years after treatment are needed.
最近积累了大量的临床证据，支持术后乳腺癌的分割放疗的疗效和安全性。这些方案通常采用更小的分割剂量（但大于 2 Gy），通过减少治疗次数，使患者更方便。此外，减少人员和机器时间的资源利用对放射治疗部门有利，并转化为更低的治疗成本。然而，为了从社会角度正式验证这种治疗方法，需要进行成本效益评估，权衡长期结果与治疗后多年产生的社会成本。
