Lin K M, Shen W W
Department of Psychiatry, Harbor-UCLA Medical Center, Torrance 90509.
J Nerv Ment Dis. 1991 Jun;179(6):346-50. doi: 10.1097/00005053-199106000-00007.
Refugees have been demonstrated to be at high risk for developing major depressive and posttraumatic stress disorders, but are often not able to benefit from modern advances in psychopharmacology. Besides difficulties in cross-cultural psychiatric diagnosis, problems also arise from cultural differences in the expectation of drug effects and in compliance. Recent evidence has suggested that pharmacokinetic and pharmacodynamic profiles of various psychotropic medications may be different in Asians than in non-Asian patients, leading to differences in dosage requirements and side effect profiles. These issues and their relevance to the care of refugee patients are reviewed.
事实证明，难民患重度抑郁症和创伤后应激障碍的风险很高，但他们往往无法从现代精神药理学进展中获益。除了跨文化精神病诊断存在困难外，药物疗效期望和依从性方面的文化差异也会引发问题。最近有证据表明，各种精神药物的药代动力学和药效学特征在亚洲患者和非亚洲患者中可能有所不同，导致剂量需求和副作用情况存在差异。本文对这些问题及其与难民患者护理的相关性进行了综述。
