Coffey M T, Shireman R B, Herman D L, Jones E E
Department of Animal Science, North Carolina State University, Raleigh 27695.
J Nutr. 1991 Jul;121(7):1047-53. doi: 10.1093/jn/121.7.1047.
Forty-eight newborn piglets were assigned to dietary regimens to examine carnitine status and lipid utilization by piglets nursing sows (Diet 1), fed a high-carnitine (1507 mumol carnitine/kg dry matter) casein-whey formula (Diet 2) or fed a low-carnitine (35 mumol carnitine/kg dry matter) egg white protein formula (Diet 3). Four piglets were killed at birth, and four per dietary group were killed at 3, 7, 14 and 21 d of age. Piglets fed Diet 3 had lower (P less than 0.01) carnitine in plasma and liver by d 7 and carnitine remained lower to d 21. Heart carnitine tended to be lower in piglets fed Diet 3, but the differences were not significant. Longissimus muscle carnitine was not affected. In vitro palmitate oxidation was lower (P less than 0.05) on d 7 in the liver from piglets fed Diet 3 but not on d 3, 14 and 21. Low dietary carnitine did not affect in vitro liver beta-hydroxybutyrate production or oxidation of palmitate by longissimus muscle. Plasma glucose and nonesterified fatty acids were higher (P less than 0.05) in piglets nursing sows than those fed Diets 2 or 3. Piglets receiving Diet 3 had reduced carnitine in plasma and certain tissues, and liver lipid oxidation was depressed on d 7 of age, compared with those receiving the other two diets. Feeding the low carnitine diet did not alter glucose status or plasma lipids and ketones.
48头新生仔猪被分配到不同饮食方案中，以研究哺乳母猪的仔猪（饮食1）的肉碱状态和脂质利用情况，喂食高肉碱（1507 μmol肉碱/千克干物质）的酪蛋白-乳清配方（饮食2）或喂食低肉碱（35 μmol肉碱/千克干物质）的蛋清蛋白配方（饮食3）。4头仔猪在出生时被处死，每个饮食组在3、7、14和21日龄时各有4头被处死。到第7天时，喂食饮食3的仔猪血浆和肝脏中的肉碱含量较低（P<0.01），且肉碱含量在第21天时仍较低。喂食饮食3的仔猪心脏肉碱含量有降低趋势，但差异不显著。背最长肌肉碱不受影响。在第7天时，喂食饮食3的仔猪肝脏中体外棕榈酸氧化较低（P<0.05），但在第3、14和21天时没有影响。低饮食肉碱不影响体外肝脏β-羟基丁酸的产生或背最长肌对棕榈酸的氧化。哺乳母猪的仔猪血浆葡萄糖和非酯化脂肪酸含量高于喂食饮食2或3的仔猪（P<0.05）。与接受其他两种饮食的仔猪相比，接受饮食3的仔猪血浆和某些组织中的肉碱减少，且在7日龄时肝脏脂质氧化受到抑制。喂食低肉碱饮食不会改变葡萄糖状态或血浆脂质和酮类。
