Véricel E, Budowski P, Crawford M A
Institute of Zoology, Regent's Park, London, England.
J Nutr. 1991 Jul;121(7):966-9. doi: 10.1093/jn/121.7.966.
Nutritional encephalomalacia (NE) was induced in young chicks using a diet low in vitamin E and containing 8% ethyl esters derived from safflower oil fatty acids (S-E group). The same diet with added alpha-tocopheryl acetate (S+E) failed to produce the pathology, and chicks receiving aerated linseed oil--high in alpha-linolenic acid and low in alpha-tocopherol (L-E)--did not develop symptoms. Formation of metabolites from labeled arachidonic acid (AA) by thrombocytes was similar in the S+E and S-E groups, yielding thromboxane B2 (TXB2) and hydroxy fatty acids as the major products. Collagen-induced thrombocyte aggregation and TXB2 production were not significantly different in the S-E and S+E groups, but aggregation values and TXB2 synthesis were significantly less in the L-E group than in the ataxic S-E chicks. Prostaglandin E2 production by aortal rings was significantly influenced by the diet; S-E yielded the highest value and L-E the lowest. These results show that alpha-linolenic acid causes alterations in the AA metabolism and thrombocyte function in young chicks.
采用低维生素E且含有8%红花油脂肪酸乙酯的日粮诱导雏鸡发生营养性脑软化症（NE组）。添加了醋酸生育酚的相同日粮（S+E组）未引发该病变，并且摄入富含α-亚麻酸且α-生育酚含量低的充气亚麻籽油的雏鸡（L-E组）未出现症状。S+E组和S-E组中，血小板由标记的花生四烯酸（AA）形成代谢物的情况相似，主要产物为血栓素B2（TXB2）和羟基脂肪酸。S-E组和S+E组中，胶原蛋白诱导的血小板聚集和TXB2生成无显著差异，但L-E组的聚集值和TXB2合成显著低于共济失调的S-E组雏鸡。主动脉环产生前列腺素E2受日粮显著影响；S-E组的值最高，L-E组的值最低。这些结果表明，α-亚麻酸会导致雏鸡AA代谢和血小板功能发生改变。
