Department of Diagnostic Radiology, Institute of Gastroenterology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
J Magn Reson Imaging. 2010 Jun;31(6):1379-86. doi: 10.1002/jmri.22184.
To quantify the accumulation of superparamagnetic iron oxide (SPIO) in patients with and without liver cirrhosis using T2 and T2* mapping.
We enrolled 10 patients without liver cirrhosis and 30 patients with liver cirrhosis (Child-Pugh class A, n = 18; and B/C, n = 12). T2 and T2* mapping were performed before and after SPIO administration. The reductions in T2 (DeltaT2) and T2* (DeltaT2*) after SPIO administration were compared between the control and liver cirrhosis groups and the control, Child-Pugh A, and Child Pugh B/C groups.
There were significant differences in DeltaT2 (22.2 +/- 4.4 and 15.1 +/- 7.0) and DeltaT2* values (24.3 +/- 3.3 and 16.8 +/- 8.1) (P = 0.005 and P < 0.001) between the control and the liver cirrhosis groups. There was a significant difference in the DeltaT2* between the Child-Pugh A and Child-Pugh B/C groups (P < 0.001) and in the DeltaT2 and DeltaT2* between the control and Child-Pugh B/C groups (P = 0.018 and P < 0.001).
DeltaT2 and DeltaT2* are significantly larger in patients without liver cirrhosis than those with liver cirrhosis. DeltaT2* is also significantly larger in Child-Pugh class A patients than those in Child-Pugh B/C.
使用 T2 和 T2* 映射定量测量有无肝硬化患者体内超顺磁性氧化铁（SPIO）的积累。
我们纳入了 10 例无肝硬化患者和 30 例肝硬化患者（Child-Pugh A 级，n=18；B/C 级，n=12）。在 SPIO 给药前后进行 T2 和 T2* 映射。比较了对照组和肝硬化组以及对照组、Child-Pugh A 级和 Child Pugh B/C 级之间 SPIO 给药后 T2 降低（DeltaT2）和 T2降低（DeltaT2）的差异。
对照组和肝硬化组的 DeltaT2（22.2±4.4 和 15.1±7.0）和 DeltaT2值（24.3±3.3 和 16.8±8.1）差异有统计学意义（P=0.005 和 P<0.001）。Child-Pugh A 级和 Child-Pugh B/C 级之间的 DeltaT2差异有统计学意义（P<0.001），对照组和 Child-Pugh B/C 级之间的 DeltaT2 和 DeltaT2*差异有统计学意义（P=0.018 和 P<0.001）。
无肝硬化患者的 DeltaT2 和 DeltaT2显著大于肝硬化患者。Child-Pugh A 级患者的 DeltaT2也显著大于 Child-Pugh B/C 级患者。
