Visionlab, Department of Physics, University of Antwerp, B-2610 Antwerp, Belgium.
J Magn Reson Imaging. 2010 Jun;31(6):1492-8. doi: 10.1002/jmri.22198.
To compare the diffusion tensor imaging (DTI) measures of multiple sclerosis (MS) patients and healthy subjects in every brain voxel and to correlate them with Paced Auditory Serial Addition Test (PASAT) scores.
Fractional anisotropy (FA), and mean, longitudinal, and transverse diffusivity are compared between control subjects and MS patients, which were subdivided as mildly and moderately impaired. In addition, PASAT scores are correlated for both MS groups with the diffusion measures. An optimized voxel based analysis (VBA) method, in terms of coregistration, atlas construction, and image smoothing, was thereby used.
Diffusion differences between the control subjects and the patients with MS were found in the corpus callosum, inferior longitudinal fasciculus, cortico spinal tracts, forceps major, superior longitudinal fasciculus, and cingulum. In addition, we observed significant correlations of the FA and PASAT scores in the left inferior longitudinal fasciculus, the forceps minor, the capsula interna and externa, the genu of the corpus callosum, the left cingulum, the superior longitudinal fasciculus, and the corona radiata.
Diffusion differences were observed between the mildly impaired MS patients and control subjects. In addition, different diffusion measures correlated with PASAT scores for cognitive decline in parietal, frontal, as well as temporal white matter (WM) regions.
比较多发性硬化症（MS）患者和健康受试者在每个脑体素中的扩散张量成像（DTI）测量值，并将其与 paced auditory serial addition test（PASAT）评分相关联。
将对照组和 MS 患者的各向异性分数（FA）、平均、纵向和横向扩散率进行比较，将 MS 患者分为轻度和中度受损组。此外，还将 PASAT 评分与 MS 组的扩散测量值相关联。为此，采用了一种基于体素的优化分析（VBA）方法，包括配准、图谱构建和图像平滑。
在胼胝体、下纵束、皮质脊髓束、内囊前肢、上纵束和扣带回中发现了对照组和 MS 患者之间的扩散差异。此外，我们观察到左下纵束、内囊后肢、内囊外囊、胼胝体膝部、左扣带回、上纵束和辐射冠的 FA 和 PASAT 评分之间存在显著相关性。
在轻度受损的 MS 患者和对照组之间观察到了扩散差异。此外，不同的扩散指标与顶叶、额叶和颞叶白质（WM）区域的 PASAT 评分相关，表明认知能力下降。
