磁共振成像在多发性硬化中的应用。
Magnetic Resonance Imaging in Multiple Sclerosis.
机构信息
Laboratory for Neuroimaging Research, Partners Multiple Sclerosis Center, Ann Romney Center for Neurologic Diseases, Departments of Neurology and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
出版信息
Cold Spring Harb Perspect Med. 2018 May 1;8(5):a028969. doi: 10.1101/cshperspect.a028969.
Since its technical development in the early 1980s, magnetic resonance imaging (MRI) has quickly been adopted as an essential tool in supporting the diagnosis, longitudinal monitoring, evaluation of therapeutic response, and scientific investigations in multiple sclerosis (MS). The clinical usage of MRI has increased in parallel with technical innovations in the technique itself; the widespread adoption of clinically routine MRI at 1.5T has allowed sensitive qualitative and quantitative assessments of macroscopic central nervous system (CNS) inflammatory demyelinating lesions and tissue atrophy. However, conventional MRI lesion measures lack specificity for the underlying MS pathology and only weakly correlate with clinical status. Higher field strength units and newer, advanced MRI techniques offer increased sensitivity and specificity in the detection of disease activity and disease severity. This review summarizes the current status and future prospects regarding the role of MRI in the characterization of MS-related brain and spinal cord involvement.
自 20 世纪 80 年代初技术发展以来，磁共振成像（MRI）迅速成为支持多发性硬化症（MS）诊断、纵向监测、治疗反应评估和科学研究的重要工具。随着该技术本身的技术创新，MRI 的临床应用也在增加；1.5T 临床常规 MRI 的广泛应用使人们能够对中枢神经系统（CNS）宏观炎症性脱髓鞘病变和组织萎缩进行敏感的定性和定量评估。然而，常规 MRI 病变测量对潜在的 MS 病理学缺乏特异性，并且仅与临床状态弱相关。更高场强单位和更新的先进 MRI 技术在检测疾病活动和严重程度方面具有更高的敏感性和特异性。本综述总结了 MRI 在 MS 相关脑和脊髓受累特征描述中的当前状况和未来前景。
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