黑色素瘤前哨淋巴结活检：约翰·韦恩癌症研究所实施该手术的技术要点。
Sentinel node biopsy in melanoma: technical considerations of the procedure as performed at the John Wayne Cancer Institute.
机构信息
John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California 90404, USA.
出版信息
J Surg Oncol. 2010 Jun 15;101(8):669-76. doi: 10.1002/jso.21581.
Abstract
Since its first description in 1990, sentinel node (SN) biopsy has become the standard for accurate staging of a melanoma-draining regional lymphatic basin. This minimally invasive, multidisciplinary technique can detect occult metastases by selective sampling and focused pathologic analysis of the first nodes on the afferent lymphatic pathway from a primary cutaneous melanoma. An understanding of preoperative lymphoscintigraphy, intraoperative lymphatic mapping, and the definition of SN are critical for surgical expertise with SN biopsy.
摘要
自 1990 年首次描述以来，前哨淋巴结 (SN) 活检已成为黑色素瘤引流区域淋巴结准确分期的标准。这种微创、多学科的技术可以通过对原发性皮肤黑色素瘤顺行淋巴途径上的第一组淋巴结进行选择性取样和集中病理分析，来检测隐匿性转移。术前淋巴闪烁显像、术中淋巴定位和 SN 的定义对于 SN 活检的手术专业知识至关重要。
相似文献
1
Sentinel node biopsy in melanoma: technical considerations of the procedure as performed at the John Wayne Cancer Institute.黑色素瘤前哨淋巴结活检：约翰·韦恩癌症研究所实施该手术的技术要点。
J Surg Oncol. 2010 Jun 15;101(8):669-76. doi: 10.1002/jso.21581.
2
The role of preoperative lymphoscintigraphy in surgery planning for sentinel lymph node biopsy in malignant melanoma.术前淋巴闪烁显像在恶性黑色素瘤前哨淋巴结活检手术规划中的作用。
Wien Klin Wochenschr. 2006 May;118(9-10):286-93. doi: 10.1007/s00508-006-0603-4.
3
Radioguided sentinel lymph node biopsy in malignant cutaneous melanoma.放射性引导下恶性皮肤黑色素瘤前哨淋巴结活检
J Nucl Med. 2002 Jun;43(6):811-27.
4
Radioisotopic lymphatic mapping of the sentinel node in melanoma: importance of immunohistochemistry.黑色素瘤前哨淋巴结的放射性同位素淋巴造影：免疫组织化学的重要性
Tumori. 2000 Jul-Aug;86(4):346-8. doi: 10.1177/030089160008600426.
5
Sentinel node identification by scintigraphic methods in cutaneous melanoma.通过闪烁显像法识别皮肤黑色素瘤中的前哨淋巴结
J Exp Clin Cancer Res. 2005 Jun;24(2):181-5.
6
Use of low-dose technetium Tc 99m sulfur colloid to locate sentinel lymph nodes in melanoma of the head and neck: preliminary study.低剂量锝 Tc 99m 硫胶体用于定位头颈部黑色素瘤前哨淋巴结的初步研究。
Laryngoscope. 2001 Aug;111(8):1366-72. doi: 10.1097/00005537-200108000-00010.
7
Implications of lymphatic drainage to unusual sentinel lymph node sites in patients with primary cutaneous melanoma.原发性皮肤黑色素瘤患者淋巴管引流至异常前哨淋巴结部位的意义。
Cancer. 2002 Jul 15;95(2):354-60. doi: 10.1002/cncr.10664.
8
Mapping the sentinel lymph node in malignant melanoma by blue dye, lymphoscintigraphy and intraoperative gamma probe.通过蓝色染料、淋巴闪烁造影术和术中γ探测仪对恶性黑色素瘤前哨淋巴结进行定位
Tumori. 2000 Jul-Aug;86(4):343-5. doi: 10.1177/030089160008600425.
9
Radioguided sentinel lymph node biopsy in patients with malignant cutaneous melanoma: the nuclear medicine contribution.放射性引导前哨淋巴结活检在恶性皮肤黑色素瘤患者中的应用：核医学的贡献
J Surg Oncol. 2004 Mar;85(3):141-51. doi: 10.1002/jso.20027.
10
Sentinel node biopsy for malignant melanoma: analysis of a four-year experience.恶性黑色素瘤前哨淋巴结活检：四年经验分析
Tumori. 2000 Jul-Aug;86(4):332-5. doi: 10.1177/030089160008600421.
引用本文的文献
1
Development of New NanoAlbumin-based Radiotracers: Preclinical Evaluation Of [Ga]Ga-DOTA-nanoHSA Conjugates for Lymphatic Imaging Applications.新型纳米白蛋白基放射性示踪剂的研发：用于淋巴成像应用的[镓]Ga-DOTA-纳米人血清白蛋白缀合物的临床前评估
Mol Imaging Biol. 2025 Sep 15. doi: 10.1007/s11307-025-02049-6.
2
A bibliometric analysis of sentinel lymph node biopsy in melanoma of the top 90 cited publications.对黑色素瘤前90篇被引用文献中前哨淋巴结活检的文献计量学分析。
Melanoma Manag. 2025 Dec;12(1):2494979. doi: 10.1080/20450885.2025.2494979. Epub 2025 Apr 28.
3
An Evaluation of Sentinel Lymph Node Biopsy Guideline Adherence in Melanoma.黑色素瘤前哨淋巴结活检指南依从性评估
Ann Surg Oncol. 2025 Feb 7. doi: 10.1245/s10434-025-16971-0.
4
Patterns in progression from early-stage melanoma to late-stage melanoma: implications for survivorship follow-up.早期黑色素瘤进展至晚期黑色素瘤的模式：对生存随访的影响。
Melanoma Manag. 2024 Dec;11(1):2424708. doi: 10.1080/20450885.2024.2424708. Epub 2024 Dec 2.
5
Tc-Tilmanocept vs. Sulfur Colloid for Sentinel Node Biopsy for Melanoma in the Head and Neck.锝-替莫西普与硫胶体用于头颈部黑色素瘤前哨淋巴结活检的对比
Indian J Surg Oncol. 2024 Mar;15(1):82-87. doi: 10.1007/s13193-023-01841-6. Epub 2023 Oct 25.
6
Evaluation of Surgical Aid of Methylene Blue in Addition to Intraoperative Gamma Probe for Sentinel Lymph Node Extirpation in 116 Canine Mast Cell Tumors (2017-2022).2017年至2022年期间，116例犬肥大细胞瘤中，除术中γ探测仪外，亚甲蓝辅助手术切除前哨淋巴结的评估
Animals (Basel). 2023 Jun 2;13(11):1854. doi: 10.3390/ani13111854.
7
More than Just Skin-Deep: A Review of Imaging's Role in Guiding CAR T-Cell Therapy for Advanced Melanoma.不止于表面：影像学在指导晚期黑色素瘤CAR-T细胞治疗中的作用综述
Diagnostics (Basel). 2023 Mar 5;13(5):992. doi: 10.3390/diagnostics13050992.
8
The Characteristics of Sentinel Lymph Node Biopsy in Cutaneous Melanoma and the Particularities for Elderly Patients-Experience of a Single Clinic.皮肤黑色素瘤前哨淋巴结活检的特点及老年患者的特殊性——单中心经验
Diagnostics (Basel). 2023 Mar 1;13(5):926. doi: 10.3390/diagnostics13050926.
9
Sentinel Lymph Node Identification in Cutaneous Head & Neck Cancer - Lymphoscintigraphy Late Phase.头颈部皮肤癌前哨淋巴结定位——淋巴闪烁显像晚期。
Laryngoscope. 2022 Nov;132(11):2164-2168. doi: 10.1002/lary.30076. Epub 2022 Feb 24.
10
Molecular phenotyping and image-guided surgical treatment of melanoma using spectrally distinct ultrasmall core-shell silica nanoparticles.采用光谱独特的超小核壳硅纳米粒子进行黑色素瘤的分子表型分析和图像引导手术治疗。
Sci Adv. 2019 Dec 4;5(12):eaax5208. doi: 10.1126/sciadv.aax5208. eCollection 2019 Dec.
本文引用的文献
1
Predictors of occult nodal metastasis in patients with thin melanoma.薄型黑色素瘤患者隐匿性淋巴结转移的预测因素
Arch Surg. 2010 Feb;145(2):137-42. doi: 10.1001/archsurg.2009.271.
2
Final version of 2009 AJCC melanoma staging and classification.2009 年 AJCC 黑色素瘤分期与分类的最终版。
J Clin Oncol. 2009 Dec 20;27(36):6199-206. doi: 10.1200/JCO.2009.23.4799. Epub 2009 Nov 16.
3
EANM-EORTC general recommendations for sentinel node diagnostics in melanoma.欧洲核医学协会-欧洲肿瘤内科学会关于黑色素瘤前哨淋巴结诊断的一般建议。
Eur J Nucl Med Mol Imaging. 2009 Oct;36(10):1713-42. doi: 10.1007/s00259-009-1228-4.
4
Sentinel lymph node accumulation of Lymphoseek and Tc-99m-sulfur colloid using a "2-day" protocol.采用“两日”方案时，Lymphoseek和锝-99m硫胶体在前哨淋巴结中的聚集情况。
Nucl Med Biol. 2009 Aug;36(6):687-92. doi: 10.1016/j.nucmedbio.2009.04.007.
5
Age-related lymphatic dysfunction in melanoma patients.黑色素瘤患者中与年龄相关的淋巴功能障碍
Ann Surg Oncol. 2009 Jun;16(6):1548-52. doi: 10.1245/s10434-009-0420-x. Epub 2009 Mar 11.
6
Importance of sentinel lymph node biopsy in patients with thin melanoma.前哨淋巴结活检在薄型黑色素瘤患者中的重要性。
Arch Surg. 2008 Sep;143(9):892-9; discussion 899-900. doi: 10.1001/archsurg.143.9.892.
7
Surgery and sentinel lymph node biopsy.手术及前哨淋巴结活检。
Semin Oncol. 2007 Dec;34(6):498-508. doi: 10.1053/j.seminoncol.2007.09.010.
8
Lymphoseek: a molecular imaging agent for melanoma sentinel lymph node mapping.Lymphoseek：一种用于黑色素瘤前哨淋巴结定位的分子成像剂。
Ann Surg Oncol. 2007 Feb;14(2):913-21. doi: 10.1245/s10434-006-9099-4. Epub 2006 Dec 5.
9
Sentinel-node biopsy or nodal observation in melanoma.黑色素瘤的前哨淋巴结活检或淋巴结观察
N Engl J Med. 2006 Sep 28;355(13):1307-17. doi: 10.1056/NEJMoa060992.
10
Lymphatic mapping and sentinel node analysis: current concepts and applications.淋巴绘图与前哨淋巴结分析：当前概念与应用
CA Cancer J Clin. 2006 Sep-Oct;56(5):292-309; quiz 316-7. doi: 10.3322/canjclin.56.5.292.
Zotero 插件