多发性硬化症患者视神经和视网膜的功能与结构评估的相关性。

Correlation between functional and structural assessments of the optic nerve and retina in multiple sclerosis patients.

机构信息

Hospital Miguel Servet, Neurofisiologia Clinica, paseo Isabel la Catolica 1-3, 50009 Zaragoza, Spain.

出版信息

Neurophysiol Clin. 2010 Jun;40(3):129-35. doi: 10.1016/j.neucli.2009.12.001. Epub 2010 Jan 14.

DOI:10.1016/j.neucli.2009.12.001

PMID:20513612

Abstract

OBJECTIVE

The aim of this study was to evaluate the correlation between functional eye examinations (visual evoked potentials: VEPs; pattern electroretinogram: PERG) and structural measurements of the optic nerve (optical coherence tomography: OCT; scanning laser polarimetry: GDx) in patients with multiple sclerosis (MS).

METHODS

Patients with definite MS and disease-free controls were enrolled in the study. VEPs and PERG were recorded in all subjetcs. Ophthalmologic examination, including visual acuity, visual field determination, OCT and GDx were performed.

RESULTS

Nineteen MS patients and 19 age- and sex-matched controls were included in the study. Significant differences between both groups were observed with respect to VEP (P100 latency and amplitude), PERG (N95 amplitude and N95/P50 ratio) and OCT parameters (average, temporal and macular volume). There were a statistically significant correlation between VEP or PERG parameters and OCT or GDx results.

CONCLUSIONS

In MS patients, axonal loss in ganglion cells can be detected with OCT and GDx. PERG is a useful complementary tool to identify this damage.

摘要

目的

本研究旨在评估多发性硬化症（MS）患者的视神经结构测量（光学相干断层扫描：OCT；扫描激光偏振计：GDx）与功能眼部检查（视觉诱发电位：VEPs；图形视网膜电图：PERG）之间的相关性。

方法

本研究纳入了明确诊断为 MS 的患者和无疾病对照组。所有受试者均记录 VEPs 和 PERG。进行眼科检查，包括视力、视野测定、OCT 和 GDx。

结果

本研究纳入了 19 例 MS 患者和 19 例年龄和性别匹配的对照组。两组之间在 VEP（P100 潜伏期和振幅）、PERG（N95 振幅和 N95/P50 比值）和 OCT 参数（平均、颞部和黄斑体积）方面存在显著差异。VEPs 或 PERG 参数与 OCT 或 GDx 结果之间存在统计学显著相关性。