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提高免疫覆盖率。

Increasing immunization coverage.

出版信息

Pediatrics. 2010 Jun;125(6):1295-304. doi: 10.1542/peds.2010-0743. Epub 2010 May 31.

DOI:10.1542/peds.2010-0743
PMID:20513736
Abstract

In 1977, the American Academy of Pediatrics issued a statement calling for universal immunization of all children for whom vaccines are not contraindicated. In 1995, the policy statement "Implementation of the Immunization Policy" was published by the American Academy of Pediatrics, followed in 2003 with publication of the first version of this statement, "Increasing Immunization Coverage." Since 2003, there have continued to be improvements in immunization coverage, with progress toward meeting the goals set forth in Healthy People 2010. Data from the 2007 National Immunization Survey showed that 90% of children 19 to 35 months of age have received recommended doses of each of the following vaccines: inactivated poliovirus (IPV), measles-mumps-rubella (MMR), varicella-zoster virus (VZB), hepatitis B virus (HBV), and Haemophilus influenzae type b (Hib). For diphtheria and tetanus and acellular pertussis (DTaP) vaccine, 84.5% have received the recommended 4 doses by 35 months of age. Nevertheless, the Healthy People 2010 goal of at least 80% coverage for the full series (at least 4 doses of DTaP, 3 doses of IPV, 1 dose of MMR, 3 doses of Hib, 3 doses of HBV, and 1 dose of varicella-zoster virus vaccine) has not yet been met, and immunization coverage of adolescents continues to lag behind the goals set forth in Healthy People 2010. Despite these encouraging data, a vast number of new challenges that threaten continued success toward the goal of universal immunization coverage have emerged. These challenges include an increase in new vaccines and new vaccine combinations as well as a significant number of vaccines currently under development; a dramatic increase in the acquisition cost of vaccines, coupled with a lack of adequate payment to practitioners to buy and administer vaccines; unanticipated manufacturing and delivery problems that have caused significant shortages of various vaccine products; and the rise of a public antivaccination movement that uses the Internet as well as standard media outlets to advance a position, wholly unsupported by any scientific evidence, linking vaccines with various childhood conditions, particularly autism. Much remains to be accomplished by physician organizations; vaccine manufacturers; third-party payers; the media; and local, state, and federal governments to ensure dependable vaccine supply and payments that are sufficient to continue to provide immunizations in public and private settings and to promote effective strategies to combat unjustified misstatements by the antivaccination movement. Pediatricians should work individually and collectively at the local, state, and national levels to ensure that all children without a valid contraindication receive all childhood immunizations on time. Pediatricians and pediatric organizations, in conjunction with government agencies such as the Centers for Disease Control and Prevention, must communicate effectively with parents to maximize their understanding of the overall safety and efficacy of vaccines. Most parents and children have not experienced many of the vaccine-preventable diseases, and the general public is not well informed about the risks and sequelae of these conditions. A number of recommendations are included for pediatricians, individually and collectively, to support further progress toward the goal of universal immunization coverage of all children for whom vaccines are not contraindicated.

摘要

1977 年,美国儿科学会发表声明,呼吁为所有无疫苗接种禁忌的儿童进行普遍免疫接种。1995 年,美国儿科学会发布了题为“实施免疫政策”的政策声明,随后在 2003 年发布了第一版声明“提高免疫覆盖率”。自 2003 年以来,免疫覆盖率持续提高,朝着实现《健康人民 2010》设定的目标取得了进展。2007 年全国免疫调查数据显示,19 至 35 个月大的儿童中有 90%接受了以下疫苗的推荐剂量:灭活脊髓灰质炎病毒(IPV)、麻疹-腮腺炎-风疹(MMR)、水痘带状疱疹病毒(VZB)、乙型肝炎病毒(HBV)和流感嗜血杆菌 b 型(Hib)。对于白喉、破伤风和无细胞百日咳(DTaP)疫苗,84.5%的儿童在 35 个月龄前接受了推荐的 4 剂。然而,《健康人民 2010》的目标是至少 80%的儿童(至少 4 剂 DTaP、3 剂 IPV、1 剂 MMR、3 剂 Hib、3 剂 HBV 和 1 剂水痘带状疱疹病毒疫苗)还没有达到,青少年的免疫接种覆盖率继续落后于《健康人民 2010》提出的目标。尽管有这些令人鼓舞的数据,但出现了许多新的挑战,这些挑战威胁到普及免疫接种覆盖率目标的持续成功。这些挑战包括新疫苗和新疫苗组合的增加,以及目前正在开发的大量疫苗;疫苗采购成本大幅上升,而向医生购买和管理疫苗的支付却不足;疫苗生产和供应方面的意外问题导致各种疫苗产品严重短缺;以及公众反疫苗运动的兴起,该运动利用互联网和传统媒体来宣传一种完全没有任何科学证据支持的观点,即疫苗与各种儿童疾病,特别是自闭症有关。医师组织;疫苗制造商;第三方付款人;媒体;地方、州和联邦政府仍有许多工作要做,以确保疫苗供应可靠且支付充足,以继续在公共和私人环境中提供免疫接种,并采取有效策略打击反疫苗运动的无端错误陈述。儿科医生应在地方、州和国家各级单独和集体开展工作,确保所有无正当禁忌症的儿童按时接受所有儿童免疫接种。儿科医生和儿科组织必须与疾病预防控制中心等政府机构合作,与家长进行有效沟通,最大限度地提高他们对疫苗整体安全性和有效性的理解。大多数父母和儿童都没有经历过许多可通过疫苗预防的疾病,公众对这些疾病的风险和后果了解甚少。为儿科医生个人和集体提出了一些建议,以支持进一步实现为所有无疫苗接种禁忌的儿童普及免疫接种的目标。

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