Neuromuscular Clinic, Department of Neurology, University Hospitals of Leicester, United Kingdom.
Curr Neuropharmacol. 2009 Dec;7(4):337-42. doi: 10.2174/157015909790031166.
Intravenous immunoglobulins (IVIg) have been shown in a number of trials, to be an effective treatment for the three main types of inflammatory neuropathies: Guillain-Barré Syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and multifocal motor neuropathy (MMN). IVIg is thought to exert its immunomodulatory effects by affecting several components of the immune system including B-cells, T-cells, macrophages, complement, cytokines and cellular adhesion molecules. This article reviews the published evidence and the principal postulated mechanisms of action of intravenous immunoglobulins with special emphasis on inflammatory neuropathies.
静脉注射免疫球蛋白 (IVIg) 在多项试验中已被证明对三种主要类型的炎症性神经病有效:格林-巴利综合征 (GBS)、慢性炎症性脱髓鞘性多发性神经病 (CIDP) 和多灶性运动神经病 (MMN)。IVIg 被认为通过影响免疫系统的几个组成部分,包括 B 细胞、T 细胞、巨噬细胞、补体、细胞因子和细胞黏附分子,发挥其免疫调节作用。本文综述了静脉注射免疫球蛋白的已发表证据和主要假定作用机制,特别强调了炎症性神经病。