静脉注射免疫球蛋白在炎症性神经病中的作用机制的最新研究进展。
Current proposed mechanisms of action of intravenous immunoglobulins in inflammatory neuropathies.
机构信息
Neuromuscular Clinic, Department of Neurology, University Hospitals of Leicester, United Kingdom.
出版信息
Curr Neuropharmacol. 2009 Dec;7(4):337-42. doi: 10.2174/157015909790031166.
Abstract
Intravenous immunoglobulins (IVIg) have been shown in a number of trials, to be an effective treatment for the three main types of inflammatory neuropathies: Guillain-Barré Syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and multifocal motor neuropathy (MMN). IVIg is thought to exert its immunomodulatory effects by affecting several components of the immune system including B-cells, T-cells, macrophages, complement, cytokines and cellular adhesion molecules. This article reviews the published evidence and the principal postulated mechanisms of action of intravenous immunoglobulins with special emphasis on inflammatory neuropathies.
摘要
静脉注射免疫球蛋白 (IVIg) 在多项试验中已被证明对三种主要类型的炎症性神经病有效：格林-巴利综合征 (GBS)、慢性炎症性脱髓鞘性多发性神经病 (CIDP) 和多灶性运动神经病 (MMN)。IVIg 被认为通过影响免疫系统的几个组成部分，包括 B 细胞、T 细胞、巨噬细胞、补体、细胞因子和细胞黏附分子，发挥其免疫调节作用。本文综述了静脉注射免疫球蛋白的已发表证据和主要假定作用机制，特别强调了炎症性神经病。
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