Fernández-Vozmediano José Manuel, Armario-Hita José Carlos
Dermatology Service, University Hospital of Puerto Real, University of Cádiz, Cádiz, Spain.
J Drugs Dermatol. 2010 Apr;9(4):381-4.
For patients with basal cell carcinoma (BCC) in whom surgical intervention is not optimal, local treatment with interferon alfa-2b is an alternative. In this study, patients with BCC of the nasal pyramid were treated with intralesional interferon alfa-2b (five million international units three times per week) for four to eight weeks. Cutaneous biopsies were performed before and after treatment for histologic examination. Twelve patients, primarily with the infiltrative histologic form (80%), were treated. Complete clinical and histologic regression was confirmed in all cases, and the aesthetic results were excellent. After four years' follow-up, no tumor persistence was observed in any patient. The most frequent adverse events were transient, mild-to-moderate flu-like symptoms in 95% of patients and asymptomatic leukopenia or neutropenia in 25%. These results suggest that intralesional interferon alfa-2b is a safe and effective nonsurgical alternative approach to treat BCC of the nasal pyramid.
对于手术干预并非最佳选择的基底细胞癌（BCC）患者，局部使用干扰素α-2b进行治疗是一种替代方法。在本研究中，对鼻锥体基底细胞癌患者采用瘤内注射干扰素α-2b（每周三次，每次500万国际单位）治疗4至8周。在治疗前后进行皮肤活检以进行组织学检查。共治疗了12例患者，主要为浸润性组织学类型（80%）。所有病例均证实临床和组织学完全消退，美学效果极佳。经过四年的随访，未观察到任何患者出现肿瘤持续存在的情况。最常见的不良事件是95%的患者出现短暂的轻至中度流感样症状，25%的患者出现无症状白细胞减少或中性粒细胞减少。这些结果表明，瘤内注射干扰素α-2b是治疗鼻锥体基底细胞癌的一种安全有效的非手术替代方法。
