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巨大侵蚀性脊柱神经鞘瘤:手术治疗

Giant erosive spinal schwannomas: surgical management.

作者信息

Ozdemir Nail, Bezircioğlu Hamdi, Akar Omer

机构信息

Department of Neurosurgery, Izmir Atatürk Training and Research Hospital, Izmir, Turkey.

出版信息

Br J Neurosurg. 2010 Oct;24(5):526-31. doi: 10.3109/02688697.2010.487129.

Abstract

Giant erosive spinal schwannomas can be distinguished from other spinal schwannomas by its growth in myofascial planes and vertebral body erosion. Therapeutic radical tumour excision without neurologic deterioration is possible in the management. Prognosis is good after total tumour removal. In this article, it is aimed to report six patients who were diagnosed as giant erosive spinal schwannomas between 2001 and 2004 according to the criteria of Sridhar et al. Three of the patients were male and three female with the age range of 16-63 (mean age 39.7). Three of the tumours were located in the cervical region, one in the lumbar region, one in the thoracic region and one in the sacral region. Total excision of the tumours was achieved in four patients. However, one additional operation was required in two patients. Follow-up periods ranged from 6 weeks to 7 years (mean follow-up 51 months). Four patients had a good clinical outcome and there were no radiologic signs of instability or recurrence. Our experience and other published literature suggest that giant erosive spinal schwannoma has significant features such as local invasive nature together with vertebral body erosion and large size but benign histology, long duration for clinical presentation, common preoperative misdiagnosis and good prognosis after total excision. These tumours rarely need spinal instrumentation because the disc capsule and ligaments remain intact even if the pedicle and posterior elements are compromised.

摘要

巨大侵蚀性脊柱神经鞘瘤可通过其在肌筋膜平面的生长及椎体侵蚀与其他脊柱神经鞘瘤相鉴别。在治疗中,进行根治性肿瘤切除且不导致神经功能恶化是可行的。肿瘤全切后预后良好。本文旨在报告2001年至2004年间根据Sridhar等人的标准被诊断为巨大侵蚀性脊柱神经鞘瘤的6例患者。其中3例为男性,3例为女性,年龄范围为16 - 63岁(平均年龄39.7岁)。3例肿瘤位于颈部,1例位于腰部,1例位于胸部,1例位于骶部。4例患者实现了肿瘤全切。然而,2例患者需要再次手术。随访时间为6周至7年(平均随访51个月)。4例患者临床结局良好,无不稳定或复发的影像学征象。我们的经验及其他已发表的文献表明,巨大侵蚀性脊柱神经鞘瘤具有显著特征,如局部侵袭性、椎体侵蚀、体积大但组织学为良性、临床表现持续时间长、术前常被误诊以及全切后预后良好。这些肿瘤很少需要脊柱内固定,因为即使椎弓根和后部结构受损,椎间盘包膜和韧带仍保持完整。

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