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帕斯卡赌注:结合连续血糖监测和连续皮下胰岛素输注。

Pascal's wager: combining continuous glucose monitoring and continuous subcutaneous insulin infusion.

机构信息

Centre of Postgraduate Medical Research and Education, Bournemouth Diabetes and Endocrine Centre, Royal Bournemouth Hospital NHS Foundation Trust, Bournemouth, UK.

出版信息

Diabetes Technol Ther. 2010 Jun;12 Suppl 1:S43-50. doi: 10.1089/dia.2010.0017.

DOI:10.1089/dia.2010.0017
PMID:20515306
Abstract

Pascal's Wager is a suggestion posed by the French Philosopher, Blaise Pascal, that even though the existence of God cannot be determined through reason, a person should wager that God exists because he or she has everything to gain and nothing to lose. In the area of consideration here, the optimum experimental trial of the combined use of continuous subcutaneous insulin infusion and real-time continuous glucose monitoring in free-living individuals with type 1 diabetes providing rock-solid evidence of clinical benefit has not been performed. Nevertheless, there is considerable enthusiasm for combining the technologies among healthcare professionals, patients, and manufacturers based on the belief that this approach to diabetes care must be beneficial beyond the available evidence (i.e., reason).

摘要

帕斯卡赌注是由法国哲学家布莱兹·帕斯卡尔提出的一种建议,即尽管上帝的存在无法通过理性来确定,但一个人应该打赌上帝存在,因为他或她有一切可赢,而没有任何可输。在本文讨论的范围内,尚未对 1 型糖尿病患者进行过在自由生活环境下联合使用连续皮下胰岛素输注和实时连续血糖监测的最佳实验性试验,以提供确凿的临床获益证据。尽管如此,医疗保健专业人员、患者和制造商非常热衷于将这两种技术结合起来,其依据是他们相信这种糖尿病治疗方法肯定会带来除现有证据(即理性)以外的益处。

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Pascal's wager: combining continuous glucose monitoring and continuous subcutaneous insulin infusion.帕斯卡赌注:结合连续血糖监测和连续皮下胰岛素输注。
Diabetes Technol Ther. 2010 Jun;12 Suppl 1:S43-50. doi: 10.1089/dia.2010.0017.
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Severe hypoglycaemia and glycaemic control in Type 1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion.1型糖尿病中的严重低血糖与血糖控制:多次每日胰岛素注射与持续皮下胰岛素输注对比的荟萃分析
Diabet Med. 2009 Mar;26(3):311-2; author reply 312-3. doi: 10.1111/j.1464-5491.2009.02668.x.
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[Insulin therapy by insulin pump: continuous or conventional self-blood glucose monitoring? ].胰岛素泵胰岛素治疗:持续自我血糖监测还是传统自我血糖监测?
Diabetes Metab. 2003 Apr;29(2 Pt 2):S54-62.
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Insulin pump treatment of childhood type 1 diabetes.儿童1型糖尿病的胰岛素泵治疗
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Deus ex machina: the use of technology in type 1 diabetes.从机器中走出的神明:1 型糖尿病中的技术应用。
Prim Care Diabetes. 2011 Oct;5(3):159-65. doi: 10.1016/j.pcd.2010.11.001. Epub 2011 Jul 2.
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Benefits of continuous subcutaneous insulin infusion in type 1 diabetes previously treated with multiple daily injections with once-daily glargine and pre-meal analogues.持续皮下胰岛素输注对既往接受每日一次甘精胰岛素和餐时胰岛素类似物多次皮下注射治疗的1型糖尿病患者的益处。
Exp Clin Endocrinol Diabetes. 2009 Sep;117(8):378-85. doi: 10.1055/s-0029-1225337. Epub 2009 Jul 23.
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No apparent local effect of insulin on microdialysis continuous glucose- monitoring measurements.胰岛素对微透析连续血糖监测测量无明显局部影响。
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Rediscovery of insulin pump treatment of childhood type 1 diabetes.胰岛素泵治疗儿童1型糖尿病的重新发现
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In Type 1 diabetic patients with good glycaemic control, blood glucose variability is lower during continuous subcutaneous insulin infusion than during multiple daily injections with insulin glargine.在血糖控制良好的1型糖尿病患者中,持续皮下胰岛素输注期间的血糖变异性低于每日多次注射甘精胰岛素期间的血糖变异性。
Diabet Med. 2008 Mar;25(3):326-32. doi: 10.1111/j.1464-5491.2007.02365.x.
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Semi-closed-loop insulin delivery systems: early experience with low-glucose insulin suspend pumps.半闭环胰岛素输送系统:低血糖胰岛素悬浮泵的早期经验
Diabetes Technol Ther. 2011 Jul;13(7):695-8. doi: 10.1089/dia.2011.0103. Epub 2011 Jun 13.

引用本文的文献

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Diabetes Spectr. 2019 Aug;32(3):226-230. doi: 10.2337/ds18-0085.
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Multicenter user evaluation of ACCU-CHEK® Combo, an integrated system for continuous subcutaneous insulin infusion.ACCU-CHEK® Combo连续皮下胰岛素输注集成系统的多中心用户评估。
J Diabetes Sci Technol. 2010 Nov 1;4(6):1400-7. doi: 10.1177/193229681000400615.