Departments of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
J Neurosurg Spine. 2010 Jun;12(6):709-13. doi: 10.3171/2009.12.SPINE09482.
Extraadrenal paragangliomas are most commonly found in the carotid body and are also found with lower frequency in the CNS. These lesions are derived from the sympathoadrenal lineage of neural crest cells. Here, the authors report a rare case of a composite paraganglioma with ganglioneuromatous components found at the filum terminale in a patient who presented with a brief history of low-back pain and paresthesias in the inguinal region. Immunohistochemical analysis of the resected lesion revealed admixed elements of neuroendocrine and neuroblastoma lineages, indicating the presence of divergent differentiation of sympathoadrenal progenitor cells. This case represents a unique opportunity to understand the cell fate of sympathoadrenal progenitor cells. Here, the authors propose that paragangliomas at the filum terminale can revert to a neural crest cell precursor fate, giving rise to divergent neoplastic populations.
肾上腺外副神经节瘤最常见于颈动脉体，也以较低的频率出现在中枢神经系统。这些病变来源于神经嵴细胞的交感肾上腺谱系。在此，作者报告了一例罕见的病例，一名患者的终丝处有混合性神经节细胞瘤成分的副神经节瘤，该患者有短暂的腰痛病史和腹股沟区域的感觉异常。对切除病变的免疫组织化学分析显示，存在神经内分泌和神经母细胞瘤谱系的混合成分，表明交感肾上腺祖细胞存在不同分化。该病例为了解交感肾上腺祖细胞的细胞命运提供了一个独特的机会。在这里，作者提出终丝处的副神经节瘤可以恢复为神经嵴细胞前体命运，从而产生不同的肿瘤群体。
