Hospital Universitário, University of Sao Paulo, Sao Paulo, Brazil.
BMC Public Health. 2010 Jun 1;10:298. doi: 10.1186/1471-2458-10-298.
Several epidemiologic studies have shown a possible association between thyroid function and cognitive decline. Our aim was to evaluate the association of subclinical hyperthyroidism and dementia in a population sample of older people
A cross-sectional study--São Paulo Ageing & Health Study (SPAH)--in a population sample of low-income elderly people > or = 65 years-old to evaluate presence of subclinical thyroid disease as a risk factor for dementia. Thyroid function was assessed using thyrotropic hormone and free-thyroxine as well as routine use of thyroid hormones or antithyroid medications. Cases of dementia were assessed using a harmonized one-phase dementia diagnostic procedure by the "10/66 Dementia Research Group" including Alzheimer's disease and vascular dementia. Logistic regression models were used to test a possible association between subclinical hyperthyroidism and dementia.
Prevalence of dementia and of subclinical hyperthyroidism were respectively of 4.4% and 3.0%. After age adjustment, we found an association of subclinical hyperthyroidism and any type of dementia and vascular dementia (Odds Ratio, 4.1, 95% Confidence Interval [95% CI] 1.3-13.1, and 5.3 95% CI, 1.1-26.4; respectively). Analyzing data by gender, we found an association of subclinical hyperthyroidism with dementia and Alzheimer's disease only for men (OR, 8.0; 95% CI, 1.5-43.4; OR, 12.4; 95% CI, 1.2-128.4; respectively). No women with subclinical hypothyroidism presented Alzheimer's disease in the sample.
The results suggest a consistent association among people with subclinical hyperthyroidism and dementia.
几项流行病学研究表明，甲状腺功能与认知能力下降之间可能存在关联。我们的目的是评估亚临床甲状腺功能亢进症与老年人人群中痴呆的关系。
一项横断面研究——圣保罗老龄化与健康研究（SPAH）——在一个低收入老年人的人群样本中进行，年龄大于或等于 65 岁，以评估亚临床甲状腺疾病作为痴呆的危险因素。使用促甲状腺激素和游离甲状腺素评估甲状腺功能，以及常规使用甲状腺激素或抗甲状腺药物。使用“10/66 痴呆研究组”的一项单相痴呆诊断程序评估痴呆病例，包括阿尔茨海默病和血管性痴呆。使用逻辑回归模型测试亚临床甲状腺功能亢进症与痴呆之间可能存在的关联。
痴呆和亚临床甲状腺功能亢进症的患病率分别为 4.4%和 3.0%。在年龄调整后，我们发现亚临床甲状腺功能亢进症与任何类型的痴呆症和血管性痴呆症之间存在关联（优势比，4.1，95%置信区间[95%CI]1.3-13.1，5.3 95%CI，1.1-26.4；分别）。按性别分析数据时，我们发现亚临床甲状腺功能亢进症与男性的痴呆症和阿尔茨海默病之间存在关联（OR，8.0；95%CI，1.5-43.4；OR，12.4；95%CI，1.2-128.4；分别）。在样本中，没有患有亚临床甲状腺功能减退症的女性患有阿尔茨海默病。
研究结果表明，亚临床甲状腺功能亢进症与痴呆之间存在一致的关联。
