Diaz-Olmos Rodrigo, Nogueira Antônio-Carlos, Penalva Daniele Queirós Fucciolo, Lotufo Paulo Andrade, Benseñor Isabela Martins
Division of Internal Medicine, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil.
Sao Paulo Med J. 2010 Jan;128(1):18-23. doi: 10.1590/s1516-31802010000100005.
Subclinical thyroid dysfunction is very common in clinical practice and there is some evidence that it may be associated with cardiovascular disease. The aim here was to evaluate the frequencies of subclinical thyroid disease and risk factors for cardiovascular disease among women at a workplace, and to evaluate the association between subclinical thyroid disease and cardiovascular risk factors among them.
Cross-sectional study on 314 women aged 40 years or over who were working at Universidade de São Paulo (USP).
All the women answered a questionnaire on sociodemographic characteristics and risk factors for cardiovascular disease and the Rose angina questionnaire. Anthropometric variables were measured and blood samples were analyzed for blood glucose, total cholesterol and fractions, high-sensitivity C-reactive protein, thyroid-stimulating hormone (TSH), free thyroxine (free-T4) and anti-thyroperoxidase antibodies (anti-TPO).
The frequencies of subclinical hypothyroidism and hyperthyroidism were, respectively, 7.3% and 5.1%. Women with subclinical thyroid disease presented higher levels of anti-TPO than did women with normal thyroid function (P = 0.01). There were no differences in sociodemographic factors and cardiovascular risk factors according to thyroid function status, except for greater sedentarism among the women with subclinical hypothyroidism. Restricting the comparison to women with subclinical hypothyroidism (TSH > 10 mIU/l) did not change the results.
In this sample of women, there was no association between poor profile of cardiovascular risk factors and presence of subclinical thyroid disease that would justify screening at the workplace.
亚临床甲状腺功能障碍在临床实践中非常常见，并且有证据表明它可能与心血管疾病相关。本研究旨在评估某工作场所女性中亚临床甲状腺疾病的发生率以及心血管疾病的危险因素，并评估她们中亚临床甲状腺疾病与心血管危险因素之间的关联。
对圣保罗大学（USP）314名40岁及以上在职女性进行的横断面研究。
所有女性均回答了关于社会人口学特征和心血管疾病危险因素的问卷以及罗斯心绞痛问卷。测量了人体测量学变量，并对血样进行了血糖、总胆固醇及其组分、高敏C反应蛋白、促甲状腺激素（TSH）、游离甲状腺素（游离T4）和抗甲状腺过氧化物酶抗体（抗TPO）分析。
亚临床甲状腺功能减退和甲状腺功能亢进的发生率分别为7.3%和5.1%。患有亚临床甲状腺疾病的女性抗TPO水平高于甲状腺功能正常的女性（P = 0.01）。根据甲状腺功能状态，社会人口学因素和心血管危险因素没有差异，只是亚临床甲状腺功能减退的女性久坐情况更多。将比较局限于亚临床甲状腺功能减退（TSH > 10 mIU/l）的女性并没有改变结果。
在这个女性样本中，心血管危险因素状况不佳与亚临床甲状腺疾病的存在之间没有关联，因此没有理由在工作场所进行筛查。
