平滑肌细胞中的 TRPC 通道。
TRPC channels in smooth muscle cells.
机构信息
The Center for Cardiovascular Sciences, Albany Medical College, Albany, NY, USA.
出版信息
Front Biosci (Landmark Ed). 2010 Jun 1;15(3):1023-39. doi: 10.2741/3660.
Abstract
Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the gastrointestinal tract. TRPC channels have recently emerged as important players in the control of smooth muscle function. This review will focus on the retrospective analysis of studies proposing contributions of TRPC channels to native calcium entry pathways in smooth muscle and to physiological and pathophysiological responses with emphasis on the vascular system.
摘要
瞬时受体电位经典型（TRPC）蛋白是广泛的 TRP 超家族中的七个（TRPC1-7）非选择性阳离子通道家族。TRPC1、TRPC3、TRPC4、TRPC5 和 TRPC6 通道在来自所有口径的人类血管的血管平滑肌细胞中和在子宫和胃肠道等器官的平滑肌中表达。TRPC 通道最近已成为控制平滑肌功能的重要参与者。本综述将重点回顾分析研究，这些研究提出 TRPC 通道对平滑肌中天然钙内流途径以及对生理和病理生理反应的贡献，重点是血管系统。
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