School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, Republic of South Africa (RSA).
Front Biosci (Landmark Ed). 2010 Jun 1;15(3):1150-63. doi: 10.2741/3667.
The 37-kDa/67 kDa laminin receptor (LRP/LR) represents a multifunctional protein. It is a receptor for viruses such as Dengue viruses, Alphaviruses and Adeno-associated viruses (AAV), as well as the cellular prion protein (PrPc) and infectious prions. Furthermore, the 37-kDa/67-kDa LRP/LR plays fundamental roles in basic cell biological processes such as cell adhesion and cell growth and acts as a key player in metastatic cancer, affecting invasion, adhesion and apoptotic processes. This review gives fundamental insights into basic cellular processes affected by LRP/LR including signal transduction and cell cycle progression and focuses on pathophysiological implications of the interaction of prion proteins, laminin, viruses and other ligands with LRP/LR affecting the development of highly-prevalent diseases such as cancer, neurodegenerative diseases such as prion disorders and Alzheimer's disease as well as viral infections. Molecular tools such as LRP/LR specific antibodies and siRNAs targeting LRP expression as possible alternative therapeutics for the treatment of neurodegenerative diseases, metastatic cancer and viral infections are emphasized.
37kDa/67kDa 层粘连蛋白受体（LRP/LR）是一种多功能蛋白。它是登革热病毒、甲病毒和腺相关病毒（AAV）等病毒的受体，也是细胞朊蛋白（PrPc）和传染性朊病毒的受体。此外，37kDa/67kDa LRP/LR 在细胞粘附和细胞生长等基本细胞生物学过程中发挥着重要作用，并且是转移性癌症的关键参与者，影响侵袭、粘附和凋亡过程。这篇综述深入探讨了 LRP/LR 影响的基本细胞过程，包括信号转导和细胞周期进展，并重点介绍了朊蛋白、层粘连蛋白、病毒和其他配体与 LRP/LR 的相互作用的病理生理学意义，这些相互作用影响着如癌症等高度流行疾病、如朊病毒病和阿尔茨海默病等神经退行性疾病以及病毒感染的发展。强调了针对 LRP/LR 的分子工具，如 LRP/LR 特异性抗体和针对 LRP 表达的 siRNA，作为治疗神经退行性疾病、转移性癌症和病毒感染的可能替代疗法。
