Clinical Experimental Oncology Laboratory, National Cancer Institute Giovanni Paolo II, Via Hahnemann, 10 - 70126 Bari, Italy.
Front Biosci (Landmark Ed). 2010 Jun 1;15(3):1172-90. doi: 10.2741/3669.
Among different pathological conditions that affect human beings, cancer has received a great deal of attention primarily because it leads to significant morbidity and mortality. This is essentially due to increasing world-wide incidence of this disease and the inability to discover the cause and molecular mechanisms by which normal human cells acquire the characteristics that define cancer cells. Since the discovery of p53 over a quarter of a century ago, it is now recognized that virtually all cell fate pathways of live cells and the decision to die are under the control of p53. Such extensive involvement indicates that p53 protein is acting as a major traffic controller in the cell signaling network. In cancer cells, many cell signaling pathways of normal human cells are rerouted towards immortalization and this is accomplished by the corruption of the main controllers of cell signaling pathways such as p53. This review highlights how p53 signaling activity is altered in cancer cells so that cells acquire the hallmarks of cancer including deregulated infinite self replicative potential.
在影响人类的各种病理条件中，癌症受到了极大的关注，主要是因为它导致了显著的发病率和死亡率。这主要是由于这种疾病在全球范围内的发病率不断增加，以及无法发现导致正常人类细胞获得定义癌细胞特征的原因和分子机制。自四分之一个多世纪前发现 p53 以来，人们现在认识到，几乎所有活细胞的细胞命运途径和死亡的决定都受到 p53 的控制。如此广泛的参与表明，p53 蛋白在细胞信号网络中充当主要的交通控制器。在癌细胞中，正常人类细胞的许多细胞信号通路被重新定向到永生化，这是通过腐败主要的细胞信号通路控制器，如 p53 来实现的。这篇综述强调了 p53 信号活性在癌细胞中是如何改变的，从而使细胞获得癌症的特征，包括失调的无限自我复制潜力。
