Sciacca Pietro, Betta Pasqua, Mattia Carmine, Li Volti Giovanni, Frigiola Alessandro, Curreri Sergio, Amato Maurizio, Distefano Giuseppe
Department of Pediatrics, Unit of Neonatology and Pediatric Cardiology, University of Catania, Via S Sofia 78, 95125 Catania, Italy.
Front Biosci (Elite Ed). 2010 Jun 1;2(3):805-9. doi: 10.2741/e141.
The aim of this study was: echocardiographical assessment of cardiac alterations in late-preterm newborns with hypoxic respiratory failure (HRF), and, study serum pentraxin-3 (PTX-3) in relation to the severity of respiratory impairment and to some echocardiographic parameters (i.e. ejection fraction (EF), stroke volume (SV) and cardiac output (CO). We enrolled in this study 40 newborn infants whose 22 (group I) with moderate HRF and 18 (group II) with severe HRF. In group I the mean values of EF, SV and CO were significantly higher than in the group II. Our results showed a significant increase of PTX-3 in group II patients at 24h of life when compared to group I. Taking patients all together (n=40), we found a significant (R=-73) reverse correlation between EF and serum values of PTX-3. PTX-3 in our patients with HRF is affected by the severity of the hypoxic insult and correlate with the cardio-vascular impairment.
对患有缺氧性呼吸衰竭（HRF）的晚期早产儿的心脏改变进行超声心动图评估，并研究血清五聚体-3（PTX-3）与呼吸功能损害严重程度以及一些超声心动图参数（即射血分数（EF）、每搏输出量（SV）和心输出量（CO））之间的关系。我们招募了40名新生儿，其中22名（第一组）患有中度HRF，18名（第二组）患有重度HRF。第一组的EF、SV和CO平均值显著高于第二组。我们的结果显示，与第一组相比，第二组患者在出生24小时时PTX-3显著升高。将所有患者（n = 40）综合考虑，我们发现EF与PTX-3血清值之间存在显著的（R = -73）负相关。我们患有HRF的患者体内的PTX-3受缺氧损伤严重程度的影响，并与心血管损害相关。
