Takakura K, Harada J, Mizogami M, Kawakami H, Goto Y
Department of Anesthesiology, Fukui Medical School.
Masui. 1991 Jan;40(1):91-5.
In a prospective, controlled, randomized trial measuring the gastric juice pH and viscosity, 30 patients under general anesthesia received M1-blocker; pirenzepine or H2-blocker; ranitidine. The gastric juice pH value was significantly higher (P less than 0.05) both in the pirenzepine and the ranitidine group than in the control group. While in the pirenzepine group the viscosity of gastric juice was unchanged, in the ranitidine group it was reduced. The results suggest that pirenzepine offers more effective prophylaxis against stress ulcer than ranitidine.
在一项测量胃液pH值和黏度的前瞻性、对照、随机试验中，30例全身麻醉患者接受了M1受体阻滞剂哌仑西平或H2受体阻滞剂雷尼替丁。哌仑西平组和雷尼替丁组的胃液pH值均显著高于对照组（P<0.05）。哌仑西平组胃液黏度未变，而雷尼替丁组胃液黏度降低。结果表明，哌仑西平预防应激性溃疡比雷尼替丁更有效。
