Naz Rajesh K, Catalano Briana
Reproductive Immunology and Molecular Biology Lab, Department of Obstetrics and Gynecology, The West Virginia University, School of Medicine, Health Sciences Center, Morgantown, WV 26505-9186, USA.
Front Biosci (Schol Ed). 2010 Jun 1;2(3):1092-112. doi: 10.2741/s120.
The knockout gene technology is an excellent tool to investigate gene function. In 2005, we reviewed 83 gene knockouts that were reported to affect female fertility. This article is an update of the previous review published in early 2005. It describes genes discovered (2004-2010) since the last review that affect female fertility. Using the database search in the Pubmed and Google Scholar search engines, 67 new genes were discovered using knockout technology that have been reported to affect female fertility. These genes were grouped into three main categories based upon the aspect of female reproductive biology that is affected by their knockout. Some of these genes may provide novel targets for developing better methods for contraception and specific diagnosis and treatment of female infertility.
基因敲除技术是研究基因功能的一项出色工具。2005年，我们回顾了83个据报道会影响雌性生育力的基因敲除案例。本文是对2005年初发表的上一篇综述的更新。它描述了自上次综述（2004 - 2010年）以来发现的影响雌性生育力的基因。通过在PubMed和谷歌学术搜索引擎中进行数据库搜索，利用基因敲除技术发现了67个据报道会影响雌性生育力的新基因。根据这些基因敲除所影响的雌性生殖生物学方面，将这些基因分为三大类。其中一些基因可能为开发更好的避孕方法以及雌性不孕症的特异性诊断和治疗提供新的靶点。
