T 细胞抗原受体的 ITAM 介导的信号转导。
ITAM-mediated signaling by the T-cell antigen receptor.
机构信息
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Cold Spring Harb Perspect Biol. 2010 Jun;2(6):a002485. doi: 10.1101/cshperspect.a002485. Epub 2010 Apr 28.
Abstract
Signal transduction by the T-cell antigen receptor (TCR) is initiated by phosphorylation of conserved motifs (ITAMs) contained within the cytoplasmic domains of the invariant subunits. TCR complexes contain a total of 10 ITAMs and this unusual configuration has prompted studies of the role of specific ITAMs, or of ITAM multiplicity, in regulating TCR-directed developmental and effector responses. Here, we summarize data generated during the past two decades and discuss how these findings have in some cases resolved, and in others complicated, outstanding questions relating to the function of TCR ITAMs.
摘要
T 细胞抗原受体 (TCR) 的信号转导是由其不变亚基胞质结构域内包含的保守基序 (ITAMs) 的磷酸化启动的。TCR 复合物总共包含 10 个 ITAMs，这种不寻常的结构促使人们研究特定 ITAMs 或 ITAM 多样性在调节 TCR 定向发育和效应器反应中的作用。在这里，我们总结了过去二十年产生的数据，并讨论了这些发现如何在某些情况下解决了与 TCR ITAMs 功能相关的悬而未决的问题，而在其他情况下又使这些问题变得复杂。
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