微小 RNA-140 和骨关节炎的沉默。
MicroRNA-140 and the silencing of osteoarthritis.
机构信息
Endocrine Unit, Massachusetts General Hospital-Harvard Medical School, Boston, Massachusetts 02114, USA.
出版信息
Genes Dev. 2010 Jun 1;24(11):1075-80. doi: 10.1101/gad.1939310.
Abstract
MicroRNAs (miRNAs) have emerged as important modulators in development, tissue homeostasis, and diseases. In this issue of Genes & Development, Miyaki and colleagues (pp. 1173-1185) report that miR-140 is involved in the pathogenesis of osteoarthritis by regulating, at least in part, ADAMTS5. Moreover, mice lacking miR-140 are dwarf as a consequence of impaired chondrocyte proliferation. This study is the first in vivo demonstration that miR-140 has a critical and nonredundant role in cartilage development and homeostasis.
摘要
MicroRNAs (miRNAs) 已成为发育、组织稳态和疾病中的重要调节因子。在本期《基因与发育》杂志上，Miyaki 及其同事（第 1173-1185 页）报告称，miR-140 通过调节 ADAMTS5 参与骨关节炎的发病机制。此外，缺乏 miR-140 的小鼠由于软骨细胞增殖受损而成为矮小型。这项研究首次在体内证明了 miR-140 在软骨发育和稳态中具有关键且不可或缺的作用。
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