Mori F, Suzuki K, Noda H, Kato T, Tsuboi H, Miyamoto M, Esato K, Imamura A, Kawahara S, Uchiyama J
First Department of Surgery, Yamaguchi University School of Medicine, Japan.
Jpn J Surg. 1991 Mar;21(2):192-200. doi: 10.1007/BF02470908.
Isolated perfused rabbit hearts were studied to compare the effects of 3 hour ischemic arrest following either calcium-free or calcium-containing cardioplegia, on the recovery of isovolumic function of the left ventricle, coronary flow, release of creatine phosphokinase and myocardial water content. The hearts perfused with the calcium-containing solution (Ca 0.5 mmol/L) showed better recovery of the developed pressure in the left ventricle, and its first derivative and compliance. Coronary flow at a constant perfusion pressure was better restored during reperfusion in the hearts with calcium-containing solution. The release of less CPK and a lower water content were also observed in the hearts reperfused with calcium-containing solution. We concluded that calcium-containing cardioplegic solution with a high concentration of magnesium (10 mmol/L) was superior to calcium-free solution for myocardial protection.
研究了离体灌注兔心，以比较无钙或含钾心脏停搏液进行3小时缺血停搏后，对左心室等容功能恢复、冠脉血流、肌酸磷酸激酶释放及心肌含水量的影响。用含钙溶液（钙0.5 mmol/L）灌注的心脏，左心室舒张末压及其一阶导数和顺应性恢复较好。在含钾溶液灌注的心脏再灌注期间，恒定灌注压下的冠脉血流恢复更好。在含钙溶液再灌注的心脏中，也观察到肌酸磷酸激酶释放较少和含水量较低。我们得出结论，高浓度镁（10 mmol/L）的含钙心脏停搏液在心肌保护方面优于无钙溶液。
