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一种用于评估填充乳牙龋齿疗效的竞争风险生存分析模型。

A competing risk survival analysis model to assess the efficacy of filling carious primary teeth.

机构信息

School of Dentistry, Cardiff University, Cardiff, UK.

出版信息

Caries Res. 2010;44(3):285-93. doi: 10.1159/000314677. Epub 2010 May 27.

Abstract

In recent years a strategy of selective, symptom-based intervention of carious primary teeth has been developed amongst some British general dental practitioners. Practice-based studies appear to provide evidence that policies of restoration of symptomless carious primary teeth do not confer any significant benefits above those associated with non-restorative care. However, results from these studies contrast with those of many clinical trials and prospective studies of primary molar restorations. In the current investigation, cohort study data from 5,168 carious primary molar teeth from 2,654 British children aged 4-5 years at baseline, augmented with Dental Practice Board treatment data, was utilised to assess the effect of restorative treatment on the likelihood of carious teeth subsequently progressing to either exfoliation or extraction. The effect of demographic and tooth level covariates on the fate of these teeth was also assessed. Multivariate multilevel parametric survival models were applied to the analysis of the carious-exfoliation and carious-extraction transitions to which the teeth were subject, assuming an underlying data hierarchy with teeth nested within individuals. Time of occurrence of caries affected survival experience, with teeth in which caries occurred later in life being associated with higher survival rates to extraction. Amongst filled teeth, later fillings were also associated with higher survival rates to extraction. Demographic and tooth level variables had a limited effect on survival experience. Treatment was found to be significantly associated with survival with respect to extraction, with survival rates of over 80% at 14 years, double those of untreated teeth.

摘要

近年来,一些英国普通牙医发展出了一种针对龋齿乳牙的选择性、基于症状的干预策略。基于实践的研究似乎提供了证据,表明对无症状龋齿乳牙进行修复的政策并不能带来任何比非修复性护理更显著的益处。然而,这些研究的结果与许多临床试验和对初级磨牙修复的前瞻性研究的结果形成对比。在当前的调查中,利用了来自 2654 名 4-5 岁英国儿童的 5168 颗龋齿乳牙的队列研究数据,这些儿童在基线时患有龋齿,同时还增加了牙科实践委员会的治疗数据,以评估修复治疗对龋齿牙齿随后进展为脱落或拔除的可能性的影响。还评估了人口统计学和牙齿水平协变量对这些牙齿命运的影响。应用多变量多层次参数生存模型对这些牙齿所经历的龋齿脱落和龋齿拔除的转变进行了分析,假设数据具有个体内嵌套牙齿的层次结构。龋齿发生的时间影响生存经验,生命后期发生龋齿的牙齿与更高的拔除生存率相关。在填充的牙齿中,较晚的填充也与更高的拔除生存率相关。人口统计学和牙齿水平变量对生存经验的影响有限。治疗与拔除的生存显著相关,14 年后的生存率超过 80%,是未治疗牙齿的两倍。

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