Fuse H, Mizuno I, Kazama T, Katayama T, Kurimoto F
Department of Urology, Faculty of Medicine, Toyama Medical & Pharmaceutical University, Japan.
Nihon Hinyokika Gakkai Zasshi. 1991 Apr;82(4):600-6. doi: 10.5980/jpnjurol1989.82.600.
We measured epidermal growth factor (EGF) in the urine of 54 untreated patients with malignant tumors (7 prostatic cancer, 11 renal tumor, 31 bladder cancer, 3 renal pelvic tumor, 2 ureter tumor) in the Toyama Medical & Pharmaceutical University Hospital. We also measured EGF in the urine of 77 normal subjects (43 males, 34 females). Urinary concentration of EGF in normal subjects decreased with increasing age. It was significantly higher in females than males (p less than 0.05). Urinary concentration of EGF in patients with prostatic cancer or renal tumor was similar to that in normal subjects. The patients with prostatic cancer controlled by estrogen showed a slightly high level of EGF in the urine. In patients with renal tumor, urinary concentration of EGF decreased after nephrectomy. Patients with bladder cancer showed a significant decrease of EGF in the urine compared with normal subjects (p less than 0.05), and urinary concentration of EGF in the patients with bladder cancer of high stage was remarkably low. Low concentration of EGF in the urine was recognized in patients with renal pelvic tumor or ureter tumor. However, the relationship between the decrease of urinary concentration of EGF in these urothelial tumors and the growth of these tumors remains to be elucidated.
我们对富山医科药科大学医院的54例未经治疗的恶性肿瘤患者（7例前列腺癌、11例肾肿瘤、31例膀胱癌、3例肾盂肿瘤、2例输尿管肿瘤）的尿液中的表皮生长因子（EGF）进行了测定。我们还对77名正常受试者（43名男性、34名女性）尿液中的EGF进行了测定。正常受试者尿液中EGF的浓度随年龄增长而降低。女性的尿液EGF浓度显著高于男性（p<0.05）。前列腺癌或肾肿瘤患者尿液中EGF的浓度与正常受试者相似。接受雌激素治疗的前列腺癌患者尿液中的EGF水平略高。肾肿瘤患者在肾切除术后尿液中EGF的浓度降低。与正常受试者相比，膀胱癌患者尿液中的EGF显著降低（p<0.05），高分期膀胱癌患者尿液中EGF的浓度极低。肾盂肿瘤或输尿管肿瘤患者尿液中的EGF浓度较低。然而，这些尿路上皮肿瘤患者尿液中EGF浓度降低与肿瘤生长之间的关系仍有待阐明。
