Sayari Sofiene, Moussi Amir, Bel Haj Salah Riadh, Gherib Souad Bakhta, Haouet Karim, Zaouche Abdeljelil
Service de Chirurgie générale A, Hôpital Charles Nicolle, Tunis.
Tunis Med. 2010 Jun;88(6):430-2.
Anorectal melanoma is a rare but highly lethal malignancy. Clinical symptoms are non-specific and treatment is still debated.
The aim of this study was to report a case concerning diagnostic and management of Anorectal melanoma.
A 66-year-old man was admitted in our surgical unit with a 3- month history of pain and rectal bleeding. Rectal examination revealed a tender mass arising from the 5 o'clock position of the anal canal that bled on touch. A provisional diagnosis of rectal polyp was made and it was removed by local excision under general anaesthesia. Histopathologic examination reported it as an anorectal malignant melanoma. The postoperative course was uneventful. Extension staging showed a 15 mm nodule on the left lung. The patient underwent a metastasectomy of the left lung. No adjuvant therapy was given. He died one year later.
With this case we want to illustrate that malignant melanoma can be difficult to diagnose, as patients have non-specific symptoms and histology may be misleading. Surgery remains the mainstay of treatment. Wide local excision combined with adjuvant oco-regional radiotherapy should be preferred when technically feasible. Abdominoperineal resection has to be done only in the case of large tumors or when the anal sphincter is involved. Overall 5-year survival is less than 20%. It's correlated to extension of disease regardless of initial surgical therapy.
肛管黑色素瘤是一种罕见但极具致死性的恶性肿瘤。临床症状不具特异性,治疗方法仍存在争议。
本研究旨在报告一例肛管黑色素瘤的诊断与治疗病例。
一名66岁男性因3个月的疼痛及直肠出血病史入住我院外科病房。直肠指检发现肛管5点位置有一触痛性肿物,触诊时出血。初步诊断为直肠息肉,并在全身麻醉下通过局部切除将其切除。组织病理学检查报告为肛管恶性黑色素瘤。术后过程顺利。扩展分期显示左肺有一个15毫米的结节。患者接受了左肺转移瘤切除术。未给予辅助治疗。一年后患者死亡。
通过该病例我们想说明,恶性黑色素瘤可能难以诊断,因为患者症状不具特异性,且组织学检查可能产生误导。手术仍然是主要的治疗方法。在技术可行的情况下,应首选广泛局部切除联合辅助性区域放疗。仅在肿瘤较大或累及肛门括约肌的情况下才进行腹会阴联合切除术。总体5年生存率低于20%。其与疾病的扩展相关,与初始手术治疗无关。