Alvarsson M, Grill V, Hamberger B, Grimelius L
endokrinologiska kliniken, Akademiska sjukhuset, Uppsala.
Lakartidningen. 1991 May 15;88(20):1896.
A single dose of 250 mg disopyramide provoked severe hypoglycaemia and confusion in a 75-year-old woman. During subsequent investigation, fasting provoked symptomatic hypoglycaemia (venous blood glucose, 1.6 mumol/1) after 23 hours, plasma concentrations of insulin and C peptide then being 19 micrograms/ml and 0.85 pmol/l, respectively; computerised tomography and ultrasonography of the pancreas n.a.d. However, at laparotomy, a 10 mm diameter insulinoma was detected by intra-operative ultrasonography and palpation. The tumour was removed. To our knowledge, this is the first reported case of an insulinoma being detected due to intake of disopyramide.
单次服用250毫克丙吡胺可使一名75岁女性发生严重低血糖和意识模糊。在随后的检查中，禁食23小时后诱发了症状性低血糖（静脉血糖为1.6微摩尔/升），此时血浆胰岛素和C肽浓度分别为19微克/毫升和0.85皮摩尔/升；胰腺的计算机断层扫描和超声检查未发现异常。然而，在剖腹手术中，通过术中超声检查和触诊发现了一个直径10毫米的胰岛素瘤。该肿瘤被切除。据我们所知，这是首例因服用丙吡胺而检测出胰岛素瘤的报告病例。
