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Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity.由组蛋白乙酰化、共调节因子和转录能力定义的具有不同功能的基因组雄激素受体占据区域。
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Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer.雄激素受体辅因子p44独特的核功能和胞质功能及其与雄激素非依赖性前列腺癌的关联
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Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor.缺乏前列腺上皮雄激素受体的小鼠中前列腺细胞增殖增加及细胞分化丧失。
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Expression profiling of the mouse prostate after castration and hormone replacement: implication of H-cadherin in prostate tumorigenesis.去势及激素替代后小鼠前列腺的表达谱分析：H-钙黏蛋白在前列腺肿瘤发生中的作用
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Roles of the androgen receptor cofactor p44 in the growth of prostate epithelial cells.雄激素受体辅因子p44在前列腺上皮细胞生长中的作用。
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[Trefoil factor 1 (pS2/TFF1), a peptide with numerous functions].[三叶因子1（pS2/TFF1），一种具有多种功能的肽]
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雄激素受体共激活因子 p44/WDR77 缺失的小鼠前列腺上皮细胞分化和增殖改变。

Altered differentiation and proliferation of prostate epithelium in mice lacking the androgen receptor cofactor p44/WDR77.

机构信息

Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030-4009, USA.

出版信息

Endocrinology. 2010 Aug;151(8):3941-53. doi: 10.1210/en.2009-1080. Epub 2010 Jun 2.

DOI:10.1210/en.2009-1080
PMID:20519372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2940529/
Abstract

Although it has been observed that various cofactors modulate activity of the androgen receptor (AR), the specific relationship between AR cofactors and prostate development and functions has not been well studied. To determine whether AR cofactor p44/WDR77 is important in prostate growth and development, we examined prostate architecture in p44/WDR77-null mice and wild-type (WT) littermates. Prostate glands from p44/WDR77-deficient animals were not only smaller than those from WT mice but also had fewer branches and terminal duct tips and were deficient in production of secretory proteins. The p44/WDR77-null prostate tissue was less differentiated and hyperproliferative relative to WT littermates. In addition, the altered expression of androgen-regulated genes was observed in the p44/WDR77-null prostate. Thus, these results suggest that the AR cofactor p44/WDR77 plays important roles in prostate growth and differentiation by modulating AR-target gene expression.

摘要

虽然已经观察到各种辅助因子调节雄激素受体 (AR) 的活性，但 AR 辅助因子与前列腺发育和功能之间的具体关系尚未得到很好的研究。为了确定 AR 辅助因子 p44/WDR77 是否对前列腺生长和发育重要，我们检查了 p44/WDR77 缺失小鼠和野生型 (WT) 同窝仔鼠的前列腺结构。p44/WDR77 缺失动物的前列腺不仅比 WT 小鼠的小，而且分支和终末导管末端更少，并且缺乏分泌蛋白的产生。p44/WDR77 缺失的前列腺组织相对于 WT 同窝仔鼠分化较少且过度增殖。此外，还观察到 p44/WDR77 缺失前列腺中雄激素调节基因的表达改变。因此，这些结果表明 AR 辅助因子 p44/WDR77 通过调节 AR 靶基因的表达在前列腺生长和分化中发挥重要作用。