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[1983年至2005年冰岛的急性会厌炎]

[Acute epiglottitis in Iceland from 1983-2005].

作者信息

Briem Birgir, Thorvardarson Ornolfur, Petersen Hannes

机构信息

Háls-, nef- og eyrnadelid, Rikshospitalet, Osló, Noregi.

出版信息

Laeknabladid. 2010 Jun;96(6):405-11. doi: 10.17992/lbl.2010.06.300.

Abstract

OBJECTIVE

To describe the changes in the epidemiology of acute epiglottitis in Iceland from 1983-2005.

METHODS

All patients with discharge diagnosis of epiglottitis during the study years were identified and diagnosis confirmed by chart review. Main outcome measures were age, gender, month/year of diagnosis, microbiology, airway management, ICU admissions, choice of antibiotics, length of hospital stay and major complications/mortality.

RESULTS

Fifty-seven patients were identified (annual incidence 0.93/100.000). The mean age was 33.3 years (1-82). Childhood epiglottitis disappeared after introduction of Haemophilus influenzae type b (Hib) vaccination in 1989 but adult disease showed non-significant increase. In the pre-vaccination era Hib was the most common organism cultured but it has not been diagnosed in Iceland since 1991 and Streptococci are now the leading cause of epiglottitis. The mean hospital stay was 5.05 nights with 51% of patients admitted to ICU. All children under 10 years and a total 30% of patients received airway intervention. Ninety percent of adults were observed without airway intervention. Major complications were rare and mortality was 0% in our series.

CONCLUSION

There have been major changes in the epidemiology of epiglottitis in Iceland during the study period. Previously a childhood disease, epiglottitis has disappeared in children and is now almost exclusively found in adults. This can be attributed to widespread Hib vaccination, eliminating the major causative agent in children. The treatment of this life-threatening disease remains a challenge. Our series suggest that it is safe to observe patients with mild/moderate symptoms without airway intervention.

摘要

目的

描述1983年至2005年冰岛急性会厌炎的流行病学变化。

方法

确定研究期间所有出院诊断为会厌炎的患者,并通过病历审查确认诊断。主要观察指标包括年龄、性别、诊断月份/年份、微生物学、气道管理、入住重症监护病房(ICU)情况、抗生素选择、住院时间以及主要并发症/死亡率。

结果

共确定57例患者(年发病率为0.93/100,000)。平均年龄为33.3岁(1至82岁)。1989年引入b型流感嗜血杆菌(Hib)疫苗后,儿童会厌炎消失,但成人病例略有增加。疫苗接种前,Hib是最常见的培养病原体,但自1991年以来冰岛未再诊断出该病原体,目前链球菌是会厌炎的主要病因。平均住院时间为5.05晚,51%的患者入住ICU。所有10岁以下儿童及30%的患者接受了气道干预。90%的成人未进行气道干预观察。主要并发症罕见,本系列研究中死亡率为0%。

结论

在研究期间,冰岛会厌炎的流行病学发生了重大变化。会厌炎以前是一种儿童疾病,现在在儿童中已消失,几乎仅见于成人。这可归因于广泛接种Hib疫苗,消除了儿童的主要病原体。治疗这种危及生命疾病仍然是一项挑战。我们的系列研究表明,对症状轻/中度患者不进行气道干预观察是安全的。

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