Kimura H, Yonemura Y, Iwasa K, Ohyama S, Kosaka T, Miwa K, Miyazaki I
Department of Surgery II, School of Medicine, Kanazawa, University, Japan.
Nihon Geka Gakkai Zasshi. 1991 Mar;92(3):288-92.
Cell nuclear DNA content was determined by flow cytometric analysis in 270 patients with advanced gastric cancer. Aneuploid DNA content was observed in 150 patients (55.6%). The DNA ploidy pattern was the third significantly prognostic factor behind peritoneal dissemination and liver metastasis in Cox regression multivariate analysis. About the relationship between DNA ploidy pattern and other prognostic factors, peritoneal dissemination and wall invasion ratio of aneuploid were significantly higher than those of diploid (p less than 0.01). Five-year survival rate of diploidy patients was significantly higher than that of aneuploidy patients. In stage I, five-year survival rate of patients with diploid tumor was 83.3% and that of patients with aneuploid tumor was 70.0%. In stage II, that of patients with diploid tumor was 81.3% and that of patients with aneuploid tumor was 66.7%. In stage III, that of patients with diploid tumor was 71.2% and that of patients with aneuploid tumor was 25.1%. In stage IV, that of patients with diploid tumor was 31.6% and that of patients with aneuploid tumor was 2.6%. Furthermore in the curative case, that of patients with diploid tumor was 77.2% and that of patients with aneuploid tumor was 48.2%. Aneuploid case has significantly worse prognosis in curative operation.
采用流式细胞术分析270例晚期胃癌患者的细胞核DNA含量。150例患者（55.6%）观察到非整倍体DNA含量。在Cox回归多因素分析中，DNA倍体模式是继腹膜播散和肝转移之后的第三个显著预后因素。关于DNA倍体模式与其他预后因素的关系，非整倍体的腹膜播散和壁浸润率显著高于二倍体（p<0.01）。二倍体患者的5年生存率显著高于非整倍体患者。在Ⅰ期，二倍体肿瘤患者的5年生存率为83.3%，非整倍体肿瘤患者为70.0%。在Ⅱ期，二倍体肿瘤患者为81.3%，非整倍体肿瘤患者为66.7%。在Ⅲ期，二倍体肿瘤患者为71.2%，非整倍体肿瘤患者为25.1%。在Ⅳ期，二倍体肿瘤患者为31.6%，非整倍体肿瘤患者为2.6%。此外，在治愈病例中，二倍体肿瘤患者为77.2%，非整倍体肿瘤患者为48.2%。非整倍体病例在根治性手术中的预后明显较差。
