巴西人群中瘦素基因变体与肥胖及代谢生物标志物之间的关系。
Relationship between variants of the leptin gene and obesity and metabolic biomarkers in Brazilian individuals.
作者信息
Hinuy Hamilton M, Hirata Mario H, Sampaio Marcelo F, Armaganijan Dikran, Arazi Simone Sorkin, Salazar Luis A, Hirata Rosario D C
机构信息
USP, São Paulo, SP, Brasil.
出版信息
Arq Bras Endocrinol Metabol. 2010 Mar;54(3):282-8. doi: 10.1590/s0004-27302010000300006.
OBJECTIVE
The relationship between variants of the leptin gene (LEP) and obesity and metabolic biomarkers was investigated in Brazilian individuals.
SUBJECTS AND METHODS
One-hundred-ten obese (BMI > 30 kg/m(2)) and 100 non-obese individuals (145 women and 65 men, aged 49 +/- 14 years) were randomly selected. Plasma leptin, glycemia, serum lipid measurements and LEP -2548G>A and 3'HVR polymorphisms were analyzed.
RESULTS
The LEP -2548GG genotype was associated with a 2.2% and 2.0% increase in BMI (p = 0.009) and plasma leptin (p = 0.031), respectively. 3'HVR I/II (classes I/I+I/II) genotypes contributed with 1.8% of BMI values (p = 0.046). LEP I/G combined genotypes (I/IGG, I/IGA and I/IIGG) were associated with obesity, and increased BMI, waist circumference, leptin and triglycerides (p < 0.05). These relationships were found in women (p < 0.05) but not in men. LEP I/G combined genotypes were not associated with hypertension, hyperglycemia, dyslipidemia and coronary artery disease.
CONCLUSIONS
LEP I/G combined genotypes are associated with obesity-related metabolic biomarkers and phenotype in a gender-dependent manner.
目的
在巴西人群中研究瘦素基因（LEP）变异与肥胖及代谢生物标志物之间的关系。
对象与方法
随机选取110名肥胖者（BMI>30 kg/m²）和100名非肥胖者（145名女性和65名男性，年龄49±14岁）。分析血浆瘦素、血糖、血脂水平以及LEP -2548G>A和3'HVR多态性。
结果
LEP -2548GG基因型分别与BMI升高2.2%和血浆瘦素升高2.0%相关（p = 0.009和p = 0.031）。3'HVR I/II（I/I+I/II类）基因型对BMI值的贡献为1.8%（p = 0.046）。LEP I/G组合基因型（I/IGG、I/IGA和I/IIGG）与肥胖相关，且BMI、腰围、瘦素和甘油三酯升高（p<0.05）。这些关系在女性中存在（p<0.05），而在男性中未发现。LEP I/G组合基因型与高血压、高血糖、血脂异常和冠状动脉疾病无关。
结论
LEP I/G组合基因型以性别依赖的方式与肥胖相关的代谢生物标志物及表型有关。
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