在埃及分离出的高致病性甲型禽流感（H5N1）病毒的抗原性和基因多样性。
Antigenic and genetic diversity of highly pathogenic avian influenza A (H5N1) viruses isolated in Egypt.
作者信息
Balish Amanda L, Davis C Todd, Saad Magdi D, El-Sayed Nasr, Esmat Hala, Tjaden Jeffrey A, Earhart Kenneth C, Ahmed Lu'ay E, Abd El-Halem Mohamed, Ali Abdel Hakem M, Nassif Samir A, El-Ebiary Elham A, Taha M, Aly Mona M, Arafa Abdelstattar, O'Neill Eduardo, Xiyan Xu, Cox Nancy J, Donis Ruben O, Klimov Alexander I
机构信息
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
出版信息
Avian Dis. 2010 Mar;54(1 Suppl):329-34. doi: 10.1637/8903-042909-Reg.1.
Highly pathogenic avian influenza A virus (H5N1) has diverged antigenically and genetically since its initial detection in Asia in 1997. Viruses belonging to clade 2.2 in particular have been reported in numerous countries with the majority occurring in Egypt. Previous reports identified antigenic similarities between viruses belonging to clade 2.2. However, poultry and human viruses isolated in northern Egypt during 2007 and 2008 were found to be antigenically distinct from other clade 2.2 viruses from this country. Genetic analysis of the hemagglutinin revealed a high degree of nucleotide and amino acid divergence. The antigenic changes in Egyptian viruses isolated during 2007-08 necessitated that two of these strains be considered as potential H5N1 pre-pandemic vaccine candidates.
高致病性甲型禽流感病毒（H5N1）自1997年在亚洲首次被发现以来，在抗原性和基因方面已经发生了分化。特别是2.2分支的病毒已在许多国家被报道，其中大多数出现在埃及。先前的报告指出了属于2.2分支的病毒之间的抗原相似性。然而，2007年和2008年在埃及北部分离出的家禽和人类病毒被发现与该国其他2.2分支病毒在抗原性上有所不同。血凝素的基因分析显示出高度的核苷酸和氨基酸差异。2007 - 2008年期间在埃及分离出的病毒的抗原变化使得其中两种毒株被视为潜在的H5N1大流行前疫苗候选毒株。
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